Cancer: A Problem in Somatic Cell Evolution

  • John Leslie Collins
  • Paul Q. Patek
  • Melvin Cohn
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 11)


Our goal is to define steps required for a cell to grow as a cancer. The complexity of the factors involved in the development of cancer make it clear that the analysis of clinical malignancy will not reveal these steps. Since these steps cannot be analyzed at the single cell level in vivo we extrapolate from the experimental to the autochthonous situation using a theory that considers the development of cancer to be a problem in somatic cell evolution.


Natural Killer Activity Associative Recognition Anchorage Independence Restricting Element Anchorage Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • John Leslie Collins
    • 1
  • Paul Q. Patek
    • 1
  • Melvin Cohn
    • 1
  1. 1.Developmental Biology LaboratoryThe Salk Institute for Biological StudiesSan DiegoUSA

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