Effects of Stable Strontium Supplementation

  • Stanley C. Skoryna
  • Martha Fuskova


Gabriel Bertrand (1), who can be regarded as the father of trace element research, established a dictum presently known as Bertrand’s law: “Plants cannot live with a deficiency, while an excess is toxic” (2). Venchikov (3) extended this concept to animal species and proposed “zoning” of the effects of trace elements into areas of deficiency, physiological levels, pharmacological action, and toxicity. One of the objectives of this classification is to eliminate the existing confusion with regard to the observations made in various species, using different routes of administration, and with respect to the interactions among trace elements and between trace and bulk elements (4). The concept of zoning of biological activity appears to provide a useful framework for description of the effects of different levels of oral intake of trace elements on a particular system or function, although the present information on some of them, including stable Sr2+, is insufficient to delineate precisely the zones of activity; the zone limits will undoubtedly change when additional data become available. The standardization of reporting will certainly facilitate advancement of research in this area.


Mitochondrial Membrane Alcoholic Hepatitis Exhaustive Exercise Mitochondrial Structure Metastatic Bone Lesion 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Stanley C. Skoryna
    • 1
  • Martha Fuskova
    • 1
  1. 1.Medical Research Unit, St. Mary’s Hospital Center and Gastrointestinal Research LaboratoryMcGill UniversityMontrealCanada

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