Strontium and Platelet Function

  • Erik H. Mürer


Of the different activities of human blood platelets aggregation, adhesion, and clot retraction require the presence of Ca2+ in the medium, while shape change and secretion can take place in EDTA medium (1–3). It is proposed, however, that all platelet activities are regulated by the intracellular Ca2+ level, similar to other cells (4,5). This is difficult to examine in platelets, since there seems to be no exchange between cytoplasmic and extracellular Ca2+. There are several indications that such an exchange can take place between the extracellular medium and membrane stores of Ca2+, but whether these membrane stores in their course are exchangeable with internal Ca2+ is completely unknown. The very rapid reactions resulting from activation of platelets are most likely to be caused by mobilization of easily accessible Ca2+—if indeed Ca is the regulator of such reactions in platelets. Whether or not we can obtain additional ion movement after the activation of platelet functions is irrelevant if these movements are not part of the platelets’ natural activation mechanism.


Divalent Cation Platelet Function Adenine Nucleotide Blood Platelet Calcium Ionophore A23187 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Erik H. Mürer
    • 1
  1. 1.Specialized Center for Thrombosis ResearchTemple University Health Sciences CenterPhiladelphiaUSA

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