Strontium and Histamine Secretion

  • J. C. Foreman


Histamine in mammalian tissues is largely stored within mast cells (1), which are connective tissue cells of unknown physiological function. Although mast cells essentially reside in connective tissue, in some species they float free in the fluid of the serous cavities such as the peritoneum. Peritoneal fluid from the rat, for example, is a source of free mast cells that can be separated from other cells and isolated for study. The basophil leukocytes of the blood also contain histamine and in some respects are similar to tissue mast cells. The question of whether the basophil leukocytes and mast cells are interchangeable and serve the same function remains unresolved and is beyond the scope of this discussion.


Mast Cell Phosphatidyl Serine Histamine Release Histamine Secretion Spontaneous Secretion 


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  1. 1.
    R. F. Riley and G. B. West, The presence of histamine in tissue mast cells, J. Physiol. Lond. 120, 528–537(1953).Google Scholar
  2. 2.
    A. R. Johnson and N. C. Moran, Selective release of histamine from rat mast cells by compound 48/80 and antigen, Am. J. Physiol. 216, 453–459 (1969).Google Scholar
  3. 3.
    W. W. Douglas, Stimulus-secretion coupling: The concept and clues from chromaffin and other cells, Br. J. Pharmacol. 34, 451–474 (1968).Google Scholar
  4. 4.
    P. Rölich, P. Anderson, and B. Uvnas, Electron microscope observations on compound 48/80-induced degranulation in rat mast cells. Evidence for sequential exocytosis of storage granules, J. Cell Biol. 51, 465–483 (1971).CrossRefGoogle Scholar
  5. 5.
    J. C. Foreman, The mechanism of spontaneous histamine release from mast cells, J. Physiol. Lond. 229, 8–9P (1973).Google Scholar
  6. 6.
    J. L. Mongar and H. O. Schild, The effect of calcium and pH on the anaphylactic reaction, J. Physiol. Lond. 140, 272–284(1958).Google Scholar
  7. 7.
    J. C. Foreman and J. L. Mongar, The role of the alkaline earth ions in anaphylactic histamine secretion, J. Physiol. Lond. 224, 753–769 (1972).Google Scholar
  8. 8.
    J. L. Mongar and H. O. Schild, Inhibition of the anaphylactic reaction, J. Physiol. Lond. 135, 301–319(1957).Google Scholar
  9. 9.
    B. Diamant and B. Uvnäs, Evidence for energy-requiring processes in histamine release and mast cell degranulation in rat tissues induced by compound 48/80, Acta Physiol. Scand. 53, 315–329 (1961).CrossRefGoogle Scholar
  10. 10.
    B. Diamant et al., ATP level and CO2 production of mast cells in anaphylaxis, Int. Archs. Allergy Appl. Immun. 47, 894–908 (1974).CrossRefGoogle Scholar
  11. 11.
    T. Johansen and N. Chakravarty, Adenosine triphosphate content of mast cells in relation to histamine release induced by anaphylactic reaction, Int. Archs. Allergy Appl. Immun. 49, 208 (1974).CrossRefGoogle Scholar
  12. 12.
    C. Peterson, Role of energy metabolism in histamine release. A study on isolated rat mast cells, Acta Physiol. Scand. Suppl. 413, 1–34 (1974).Google Scholar
  13. 13.
    H. Moussatche and A. Provoust-Danon, Influence of oxidative phosphorylation inhibitors on the histamine release in the anaphylactic reaction in vitro, Experientia 14, 414–415 (1958).CrossRefGoogle Scholar
  14. 14.
    H. Yamasaki and K. Endo, Effects of 2-deoxyglucose, phlorizin, insulin and ouabain on glucose-dependent anaphylactic histamine release from guinea-pig lung, Jpn. J. Pharmac. 15, 48–56 (1965).CrossRefGoogle Scholar
  15. 15.
    H. O. Schild, Histamine release and anaphylactic shock in isolated lungs of guinea pigs, Quart. J. Exp. Physiol. 26, 166–179(1936).Google Scholar
  16. 16.
    E. S. K. Assem and H. O. Schild, Inhibition by sympathomimetic amines of histamine release by antigen in passively sensitized human lung, Nature (London) 224, 1028–1029 (1969).CrossRefGoogle Scholar
  17. 17.
    W. J. Koopman, R. P. Orange, and K. F. Austen, Modulation of the IgE mediated release of SRS-A by agents influencing the level of cyclic 3′5′-AMP, J. Immun. 105, 1096–1102 (1970).Google Scholar
  18. 18.
    M. Kaliner and K. F. Austen, Cyclic AMP, ATP and reversed anaphylactic histamine release in mast cells, J. Immun. 112, 664–674 (1974).Google Scholar
  19. 19.
    A. R. Johnson, N. C. Moran, and S. E. Meyer, Cyclic AMP content and histamine release in mast cells, J. Immun. 112, 511–519 (1974).Google Scholar
  20. 20.
    J. H. Baxter, Histamine release from rat mast cells by dextran: Effects of adrenergic agents, theophylline and other drugs, Proc. Soc. Exp. Biol Med. 141, 576–581 (1972).Google Scholar
  21. 21.
    F. A. Dodge, R. Miledi, and R. Rahamimoff, Strontium and quantal release of transmitter at the neuromuscular junction, J. Physiol. Lond. 200, 267–283 (1969).Google Scholar
  22. 22.
    W. W. Douglas and R. P. Rubin, The effects of alkaline earth and other divalent cations on adrenal medullary secretion, J. Physiol. Lond. 175, 231–241 (1964).Google Scholar
  23. 23.
    M. Buchs et al., Strontium a substitute for calcium in the process leading to neurohypophysial hormone secretion, J. Physiol. Lond. 222, 168P(1972).Google Scholar
  24. 24.
    S. M. Kirpekar and Y. Misu, Release of noradrenaline by splenic nerve stimulation and its dependence on calcium, J. Physiol. Lond. 188, 219–234 (1967).Google Scholar
  25. 25.
    J. L. Mongar, in: Calcium and Cellular Function (A. W. Cuthbert, ed.), pp. 280–283, Macmillan, London (1970).Google Scholar
  26. 26.
    O. Arunlakshana and H. O. Schild, Quantitative uses of drug antagonists, Br. J. Pharmac. Chemother. 14, 48–58 (1959).Google Scholar
  27. 27.
    R. P. Stephenson, A modification of receptor theory, Br. J. Pharmac. Chemother. 11, 279–393 (1956).Google Scholar
  28. 28.
    J. C. Foreman, Spontaneous histamine secretion from mast cells in the presence of Sr, J. Physiol. Lond. 271, 215–232(1977).Google Scholar
  29. 29.
    M. W. Greaves and J. L. Mongar, Mechanism of the anaphylactic reaction, Proc. 3rd Int. Pharmac. Meeting, 11, 45–63 (1966).Google Scholar
  30. 30.
    J. C. Foreman, Unpublished observations (1977).Google Scholar
  31. 31.
    A. Goth, H. R. Adams and M. Knoohuizen, Phosphatidyl serine: Selective enhancer of histamine release, Science 173, 1034–1035 (1971).CrossRefGoogle Scholar
  32. 32.
    J. L. Mongar and P. Svec, The effect of phospholipids on anaphylactic histamine release, Br. J. Pharmac. 46, 741–752 (1972).Google Scholar
  33. 33.
    J. C. Foreman and J. L. Mongar, The interaction of calcium and strontium with phosphatidyl serine in the anaphylactic secretion of histamine, J. Physiol. Lond. 230, 493–507 (1973).Google Scholar
  34. 34.
    J. C. Foreman, A pharmacological approach to the study of the role of calcium in the secretion of histamine from mast cells, Ph.D. thesis, University of London (1973).Google Scholar
  35. 35.
    J. C. Foreman and L. G. Garland, Desensitization in the process of histamine secretion induced by antigen and dextran, J. Physiol. Lond. 239, 381–391 (1974).Google Scholar
  36. 36.
    J. H. Baxter and R. Adamik, Control of histamine release: Effects of various conditions on rate of release and rate of cell desensitization, J. Immun. 114, 1034–1041 (1975).Google Scholar
  37. 37.
    B. Diamant et al., Effect of divalent cations and metabolic energy on the anaphylactic histamine release from rat peritoneal mast cells, Int. Archs Allergy Appl. Immun. 47, 412–424 (1974).CrossRefGoogle Scholar
  38. 38.
    P. W. Reed and H. A. Lardy, A 23187: A divalent cation ionophore, J. Biol. Chem. 247, 6970–6977(1972).Google Scholar
  39. 39.
    A. H. Caswell and B. C. Pressman, Kinetics of transport of divalent cations across sarcoplasmic reticulum vesicles induced by ionophores, Biochem. Biophys. Res. Commun. 49, 292–298(1972).CrossRefGoogle Scholar
  40. 40.
    J. C. Foreman, J. L. Mongar, and B. D. Gomperts, Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process, Nature (London) 245, 249–251 (1973).CrossRefGoogle Scholar
  41. 41.
    J. C. Foremann, M. B. Hallett, and J. L. Mongar, Movement of Sr ions into mast cells and its relationship to the secretory response, J. Physiol. Lond. 271, 233–251 (1977).Google Scholar
  42. 42.
    J. C. Foreman, M. B. Halle, and J. L. Mongar, The relationship between histamine secretion and 45Ca-uptake by mast cells, J. Physiol. Lond. 271, 193–214 (1977).Google Scholar
  43. 43.
    R. P. Rubin, et al., Inhibition of catecholamine secretion and calcium exchange in perfused cat adrenal glands by tetramine and magnesium, J. Pharmac. Exp. Ther. 155, 463–471 (1967).Google Scholar
  44. 44.
    M. J. Berridge, Interaction of cyclic nucleotides and calcium in the control of cellular activity, Adv. Cyclic Nucleotide Res. 6, 1–98 (1975).Google Scholar
  45. 45.
    J. C. Foreman, L. G. Garland, and J. L. Mongar, The role of calcium in secretory processes: model studies in mast cells, in: Calcium in Biological Systems, Society for Experimental Biology Symposium XXX (C. J. Duncan, ed.), pp. 193–218, Cambridge University Press, Cambridge (1976).Google Scholar
  46. 46.
    D. Lagunoff, Contributions of electron microscopy to the study of mast cells, J. Invest. Derm. 58, 296–311 (1972).CrossRefGoogle Scholar
  47. 47.
    C. M. Trotter and T. S. C. Orr, A fine structure study of some cellular components in allergic reactions. I. Degranulation of human mast cells in allergic asthma and perennial rhinitis, Clin. Allergy 3, 411–425(1973).CrossRefGoogle Scholar
  48. 48.
    P. Röhlich, Membrane associated actin filaments in the cortical cytoplasm of the rat mast cell, Exp. Cell Res. 93, 293–298 (1975).CrossRefGoogle Scholar
  49. 49.
    D. H. Jenkinson, The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction, J. Physiol Lond. 138. 434–444 (1957).Google Scholar
  50. 50.
    F. A. Dodge and R. Rahamimoff, Co-operative action of calcium ions in transmitter release at the neuromuscular junction, J. Physiol. Lond. 193, 419–432 (1967).Google Scholar
  51. 51.
    R. F. Burton and J. R. Loudon, The antagonistic actions of calcium and magnesium on the superfused ventricles of the snail Helix pomatia, J. Physiol. Lond. 220, 363–381 (1972).Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. C. Foreman
    • 1
  1. 1.Department of PharmacologyUniversity College LondonLondonUK

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