Effects of Calcium, Magnesium, and Strontium on Drug-Receptor Interactions

  • Issei Takayanagi


During the past decade many investigators became interested in drug-receptor interactions. Generally speaking, in drug-receptor interactions ionic combination between the cationic head of the drug and the anionic site of the receptors is involved (1). Recently some investigators have suggested that Ca2+ ions are involved in the interaction of certain agonists with their receptors; for instance, Belleau (2) based his proposition on theoretical model of the a adrenoceptors. Wooley and Campbell (3) based their model on experimental observations of the interactions of serotonin with a lipid isolated from intestinal cell membranes, which they called serotonin receptors. Nonetheless, the evidence that divalent cations are involved in the drug-receptor interactions is slight. In this chapter we attempted to determine which of divalent cations are necessary for drug-receptor interactions under physiological conditions and furthermore, to test whether or not Sr2+ ions and other divalent cations can substitute for Ca2+ ions and Mg2+ ions in these interactions.


Divalent Cation Microsomal Fraction Free Solution Histamine Receptor Competitive Antagonist 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Issei Takayanagi
    • 1
  1. 1.Department of Chemical Pharmacology, School of Pharmaceutical SciencesToho UniversityMiyama, ChibaJapan

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