Divalent Cations and Regulation of Cyclic Nucleotides in Nervous Systems

  • Edward W. Troyer
  • James A. Ferrendelli


It is well known that much of the intercellular communication in the central nervous system is chemically mediated by neurotransmitters or “neuroactive” substances. These intercellular “first messengers” interact with specific portions of plasma membranes and may produce changes in membrane potential and/or alter several intracellular metabolic processes. There is increasing evidence that the Ca2+ ion, adenosine 3’,5’-monophosphate (cyclic AMP), and perhaps guanosine 3’,5’-monophosphate (cyclic GMP) act as intracellular second messengers to mediate the actions of several neurotransmitters, hormones, and other substances in CNS as well as in other tissues. In many processes there appears to be a close interrelationship between the Ca2+ion and cyclic nucleotide and each may influence the metabolism and/or subcellular distribution or concentration of the other. This chapter reviews only one aspect of the interrelationship between cyclic nucleotides and Ca2+, namely the influence of Ca2+ and other divalent cations on cyclic AMP and cyclic GMP regulation in nervous tissue. For a more exhaustive review of cyclic nucleotides and divalent cations in cellular biology, the reader is referred to the recent reviews of Berridge (1) and Rasmussen and Goodman (2).


Adenylate Cyclase Divalent Cation Cyclic Nucleotide Guanylate Cyclase Superior Cervical Ganglion 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Edward W. Troyer
    • 1
  • James A. Ferrendelli
    • 1
  1. 1.Department of Neurology and Neurological SurgeryWashington University School of MedicineSt. LouisUSA

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