• Herbert L. DuPont
  • Larry K. Pickering
Part of the Current Topics in Infectious Disease book series (CTID)


Amebiasis is a ubiquitous disease which is a particularly important problem in developing tropical countries. The causative agent, Entamoeba histolytica, was first described in 1875 by Lösch, a Russian physician in St. Petersburg.1 He described the organisms in detail and called them Amebae coli. In a careful pathologic and clinical review in 1891, Councilman and Lefleur2 described amebic dysentery as a distinct entity characterized by ulceration of the colon wherein the ulcers were undermined without products of inflammation. They furthermore indicated that liver abscess often complicated intestinal disease with occasional extension of the abscess to the lung. The true pathogenic potential of E. histolytica for humans was established in 1911–1913 by a series of studies of experimental infection induced in volunteers.3,4 Filipino prison volunteers who ingested E. histolytica cysts developed dysentery, and stools were shown to contain the amebae. In 1919, the four species of commensal amebae were distinguished from E. histolytica.5


Liver Abscess Bacillary Dysentery Hepatic Abscess Entamoeba Histolytica Intestinal Protozoan 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Lösch, F. Massenhafte Entwickelung von Amöben im Dickdarm. Virchows Arch. Pathol. Anat. 65:196–211, 1875.Google Scholar
  2. 2.
    Councilman, W. T., Lafleur, H. A. I. Amoebic dysentery. Johns Hopkins Hosp. Rep. Rep. Pathol. 7:(7–9) 395–548, 1891.Google Scholar
  3. 3.
    Walker, E. L. A comparative study of the amoebae in the Manila water supply, in the intestinal tract of healthy persons, and in amoebic dysentery. Philipp. J. Sci. 6:259–279, 1911.Google Scholar
  4. 4.
    Walker, E. L., Sellards, A. W. Experimental entamoebic dysentery. Philipp. J. Sci. Sect. B 8:253–331, 1913.Google Scholar
  5. 5.
    Dobell, C. The Amoebae Living in Man. John Bale, Sons & Danielsson Ltd., London, 1919, 155 pp.CrossRefGoogle Scholar
  6. 6.
    Westphal, A. Betrachtungen und experimentelle Unterschungen zur Virulenz der Entamoeba histolytica beim Menschen. Arch. Schiffs Trop. Hyg. 41:262–280, 1937.Google Scholar
  7. 7.
    Baetjer, W. A., Sellards, A. W. Continuous propagation of amoebic dysentery in animals. Johns Hopkins Hosp. Bull. 25:165–173, 1914.Google Scholar
  8. 8.
    Boeck, W. C., Drbohlav, J. The cultivation of Endamoeba histolytica. Am. J. Hyg. 5:371–407, 1925.Google Scholar
  9. 9.
    Spector, B. K. A comparative study of cultural and immunological methods of diagnosing infections with Endamoeba histolytica. J. Prey. Med. 6:117–128, 1932.Google Scholar
  10. 10.
    Deschiens, R. Le rôle de la flore bactérienne, associée a l’amibe dysentérique, dans l’amibiase. Ann. Int. Pasteur 61:5–32, 1938.Google Scholar
  11. 11.
    Padilla y Padilla, C. A., Padilla, G. M. Amebiasis in Man: Epidemiology, Therapeutics, Clinical Correlations and Prophylaxis. Charles C. Thomas, Springfield, Ill., 1974.Google Scholar
  12. 12.
    Juniper, K., Jr. Amebiasis in the United States. Bull. N.Y. Acad. Med. 47:448–461, 1971.PubMedGoogle Scholar
  13. 13.
    Brooke, M. M. Epidemiology of amebiasis in the U.S. J. Am. Med. Assoc. 188:519–521, 1964.CrossRefGoogle Scholar
  14. 14.
    Burrows, R. B. Prevalence of amebiasis in the United States and Canada. Am. J. Trop. Med. 10:172–184, 1961.Google Scholar
  15. 15.
    Craig, C. F. The Etiology,Diagnosis and Treatment of Amebiasis. Williams & Wilkins, Baltimore, 1944.Google Scholar
  16. 16.
    Andrews, J. Incidence of intestinal protozoa with special reference to epidemiology of amoebiasis in population of Fresnillo, Zacatecas, Mexico. Am. J. Hyg. 19:713–733, 1934.Google Scholar
  17. 17.
    Hinman, E. H., Kampmeier, R. H. Clinical intestinal amebiasis; study of 400 cases from Charity Hospital at New Orleans. Am. J. Trop. Med. 17:263–278, 1937.Google Scholar
  18. 18.
    Ivanhoe, G. L. Studies on the transmission of amebiasis in a children’s home in New Orleans. Am. J. Trop. Med. 23:401–419, 1943.Google Scholar
  19. 19.
    Frye, W. W., Meleney, H. E. Investigations of Endamoeba histolytica and other intestinal protozoa in Tennessee: IV. A study of flies, rats, mice and some domestic animals as possible carriers of the intestinal protozoa of man in a rural community. Am. J. Hyg. 16:729–749, 1932.Google Scholar
  20. 20.
    Kean, B. H. Venereal amebiasis. N.Y. State J. Med. 76:930–931, 1976.PubMedGoogle Scholar
  21. 21.
    Hardy, A. V., Spector, B. K. Occurrence of infestations with E. histolytica associated with water-borne epidemic diseases. Public Health Rep. 50:323–334, 1935.CrossRefGoogle Scholar
  22. 22.
    McCoy, G. W., Hardy, A. V., Gorman, A. E., et al. Epidemic amebic dysentery: The Chicago outbreak of 1933. Natl. Inst. Health Bull. No. 166, 1936.Google Scholar
  23. 23.
    LeMaistre, C. A., Sappenfield, R., Culbertson, C., et al. Studies of a water-borne outbreak of amebiasis, South Bend, Indiana: I. Epidemiological aspects. Am. J. Hyg. 64:30–45, 1956.PubMedGoogle Scholar
  24. 24.
    Krogstad, D. J., Spencer, H. C., Jr., Healy, G. R., et al. Amebiasis: Epidemiologic studies in the United States, 1972–1974. Ann. Intern. Med. 88:89–97, 1978.PubMedGoogle Scholar
  25. 25.
    Abbruzzese, A. A. Hepatic amebiasis. Am. J. Gastroenterol. 54:464–469, 1970.PubMedGoogle Scholar
  26. 26.
    Sheehy, T. W. Amebic liver abscess. GP38:94–104, 1968.Google Scholar
  27. 27.
    Elsdon-Dew, R. Amebiasis as a world problem. Bull. N.Y. Acad. Med. 47:438–447, 1971.PubMedGoogle Scholar
  28. 28.
    Jarumilinta, R., Kradolfer, F. The toxic effect of Entamoeba histolytica on leucocytes. Ann. Trop. Med. Parasitol. 58:375–381, 1964.PubMedGoogle Scholar
  29. 29.
    Eaton, R. D. P., Meerovitch, E., Costerton, J. W. The functional morphology of pathogenicity in Entamoeba histolytica. Ann. Trop. Med. Parasitol. 64:299–304, 1970.PubMedGoogle Scholar
  30. 30.
    Knight, R., Bird, R. G., McCaul, T. F., Fine structural changes at Entamoeba histolytica rabbit kidney cell (RK13) interface. Ann. Trop. Med. Parasitol. 69:197–202, 1975.PubMedGoogle Scholar
  31. 31.
    Mattern, C. F. T., Keister, D. B., Caspar, P. A. Experimental amebiasdis: III. A rapid in vitro essay for virulence of Entamoeba histolytica. Am. J. Trop. Med. Hyg. 27:882–887,1978.PubMedGoogle Scholar
  32. 32.
    Anderson, H. H., Bostick, W. L., Johnstone, H. G. Amebiasis: Pathology,Diagnosis and Chemotherapy. Charles C. Thomas, Springfield, Ill., 1953.Google Scholar
  33. 33.
    Woolley, P. G., Musgrave, W. E. The pathology of intestinal amebiasis. J. Am. Med. Assoc. 45:1371–1378, 1905.CrossRefGoogle Scholar
  34. 34.
    Harris, H. F. Amoebic dysentery. Am. J. Med. Sci. 115:384–413, 1898.CrossRefGoogle Scholar
  35. 35.
    Clark, H. C. The distribution and complications of amebic lesions found in 186 postmortem examinations. Am. J. Trop. Med. 5:157–171, 1925.Google Scholar
  36. 36.
    Hoare, C. A. Parasitological reviews: The commensal phase of Entamoeba histolytica. Exp. Parasitol. 1:411–427.1962.CrossRefGoogle Scholar
  37. 37.
    Faust, E. C. Amebiasis in the New Orleans population as revealed by autopsy examination of accident cases. Am. J. Trop. Med. 21:35–48, 1941.Google Scholar
  38. 38.
    Stone, W. S. A method of producing encystment in cultures of Endomoeba histolytica. Am. J. Trop. Med. 15:681–684, 1935.Google Scholar
  39. 39.
    Brady, F. J., Jones, M. F., Newton, W. L. Effect of chlorination of water on viability of cysts of Endamoeba histolytica. War Med. 3:409–419, 1943.Google Scholar
  40. 40.
    Phillips, B. P., Wolfe, P. A., Rees, C. W., et al. Studies on ameba-bacteria relationship in amebiasis; comparative results of intracecal inoculation of germ-free, monocontaminated, and conventional guinea pigs with Entamoeba histolytica. Am. J. Trop. Med. 4:675–692, 1955.Google Scholar
  41. 41.
    Palmer, R. B. Changes in the liver in amebic dysenterry; with special reference to the origin of amebic abscess. Arch. Pathol. (Chicago) 25:327–335, 1938.Google Scholar
  42. 42.
    Kean, B. H. The nature of diffuse amebic hepatitis. Am. J. Dig. Dis. 2:342–347, 1957.PubMedCrossRefGoogle Scholar
  43. 43.
    Powell, S. J. The serum protein pattern, liver function tests and hematological findings in the differential diagnosis of amebic liver abscess. Am. J. Trop. Med. Hyg. 8:337–341, 1959.PubMedGoogle Scholar
  44. 44.
    Payne, A. M. M. Amoebic dysentery in Eastern India. Lancet 1:206–209, 1945.CrossRefGoogle Scholar
  45. 45.
    James, K. L. Surgical complications of amoebic dysentery. Proc. R. Soc. Med. 39:766–768,1946.Google Scholar
  46. 46.
    Nandi, A. K. Amoebic hepatitis and hepatic abscess: Diagnosis and management. J. Indian Med. Assoc. 25:87, 1955.PubMedGoogle Scholar
  47. 47.
    Maegraith, B. G., Harinasuta, C. Experimental amoebic infection of liver in guinea pigs: I. Infection via the mesenteric vein and via the portal vein. Ann. Trop. Med. 48:421–433, 1954.Google Scholar
  48. 48.
    Rogers, L. Amoebic liver abscess: Its pathology, prevention and cure. Lancet 1: 677–684,1922.CrossRefGoogle Scholar
  49. 49.
    Sérégé, H. Contribution a l’étude de la circulation du sang porte dans le foie et des localizations lobaires hépatiques. J. Med. Bordeaux 32:271–275, 1901.Google Scholar
  50. 50.
    Sérégé, H. Etude sur l’indépendence anatomique et physiologique des lobes du foie. J.Méd Bordeaux 32:327–357, 1902.Google Scholar
  51. 51.
    Copher, G. H., Dick, B. M. “Stream line” phenomena in the portal vein and the selective distribution of portal blood in the liver. Arch. Surg. 127:408–419, 1928.CrossRefGoogle Scholar
  52. 52.
    Biagi, F., Robledo, E., Servin, H., et al. Influence of some steroids in the experimental production of amebic hepatic abscess. Am. J. Trop. Med. Hyg. 12:318–320, 1993.Google Scholar
  53. 53.
    Eisert, J., Hannibal, J. E., Sanders, S. L. Fatal amebiasis complicating corticosteroid management of pemphigus vulgaris. N. Engl. J. Med. 25:843–845, 1959.CrossRefGoogle Scholar
  54. 54.
    McAllister, T. A. Diagnosis of amoebic colitis on routine biopsies from rectum and sigmoid colon. Br. Med. J. 1:362–364, 1962.PubMedCrossRefGoogle Scholar
  55. 55.
    Kanani, S. R., Knight, R. Relapsing amoebic colitis of 12 years’ standing exacerbated by corticosteroids. Br. Med. J. 2:613–614, 1999.CrossRefGoogle Scholar
  56. 56.
    Mody, V. R. Corticosteroids in latent amoebiasis. Br. Med. J. 2:1399, 1959.CrossRefGoogle Scholar
  57. 57.
    Wagner, V. P., Smale, L. E., Lischke, J. H. Amebic abscess of the liver and spleen in pregnancy and the puerperium. Obstet. Gynecol. 45:562–565, 1975.PubMedGoogle Scholar
  58. 58.
    Abioye, A. A. Fatal amoebic colitis in pregnancy and puerperium: A new clinico-pathological entity. J. Trop. Med. Hyg. 76:97–100, 1973.PubMedGoogle Scholar
  59. 59.
    Lewis, E. A., Antia, A. U. Amoebic colitis: Review of 295 cases. Trans. R. Soc. Trop. Med. Hyg. 63:633–638, 1999.CrossRefGoogle Scholar
  60. 60.
    Brandt, H., Tamayo, R. P. Pathology of human amebiasis. Hunt. Pathol. 1:351–385, 1970.CrossRefGoogle Scholar
  61. 61.
    Craig, C. F. The occurrence of endamebic dysentery in the troops serving in the El Paso district from July, 1916 to December, 1916. Mil. Surg. 40:286–302, 1917.Google Scholar
  62. 62.
    Martin, G. A., Garfinkel, B. T., Brooke, M. M. et al. Comparative efficacy of amebicides and antibiotics in acute amebic dysentery used alone and in combination in five-hundred thirty-eight cases. J. Am. Med. Assoc. 151:1055–1059, 1953.Google Scholar
  63. 63.
    Schmerin, M. J., Gelston, A., Jones, T.A C. Amebiasis: An increasing problem among homosexuals in New York City, J. Am. Med. Assoc. 238:1386–1387, 1977.CrossRefGoogle Scholar
  64. 64.
    Wilmot, A. J. Clinical Amoebiasis. F. A. Davis Co., Philadelphia, 1962.Google Scholar
  65. 65.
    Kean, B. H., Gilmore, H. R., Jr., Van Stone, W. W. Fatal amebiasis: Report of 148 fatal cases from the Armed Forces Institutes of Pathology. Ann. Intern. Med. 44:831–843, 1956.PubMedGoogle Scholar
  66. 66.
    Evans, T. C. The surgical aspect of amoebiasis. Trans. R. Soc. Trop. Med. Hyg. 19:282–311,1925.CrossRefGoogle Scholar
  67. 67.
    Ochsner, A., DeBakey, M. Surgical amebiasis. New Int. Clin. 1:68–99, 1942.Google Scholar
  68. 68.
    Hawe, P. The surgical aspect of intestinal amebiasis. Surg. Gynecol. Obstet. 81:387–404,1945.Google Scholar
  69. 69.
    Barker, E. M. Colonic perforations in amoebiasis. S. Afr. Med. J. 32:634–638, 1958.PubMedGoogle Scholar
  70. 70.
    Sawitz, W. G., Faust, E. C. The probability of detecting intestinal protozoa by successive stool examinations. Am. J. Trop. Med. 22:131–136, 1942.Google Scholar
  71. 71.
    Stamm, W. P., II. The laboratory diagnosis of clinical amoebiasis. Trans. R. Soc. Trop. Med. Hyg. 51:306–312, 1957.PubMedCrossRefGoogle Scholar
  72. 72.
    Rail, G. A. The use of the sigmoidoscope in the diagnosis and prognosis of amoebic dysentery. J. Trop. Med. Hyg. 49:68–69, 1946.PubMedGoogle Scholar
  73. 73.
    Healy, G. R. Laboratory diagnosis of amebiasis. Bull. N.Y. Acad. Med. 47:478–493, 1971.PubMedGoogle Scholar
  74. 74.
    Relier, L. B. Rivas, E. N., Masferrer, R., et al. Epidemic Shiga-bacillus dysentery in Central America: Evolution of the outbreak in El Salvador, 1969–70. Am. J. Trop. Med. Hyg. 20:934–940, 1971.Google Scholar
  75. 75.
    Cifarelli, P. S. Acute amebic colitis: Prospective analysis. N.Y. State J. Med. 69:815–818,1969.PubMedGoogle Scholar
  76. 76.
    Healy, G. R., Kagan, I. G., Melvin, D. M. Parasitic infections. In H. L. Bodily (ed.), Diagnostic Procedures for Bacterial, Mycotic and Parasitic Infections. American Public Health Association, New York, 1970, pp. 724–790.Google Scholar
  77. 77.
    Sapero, J. J., Lawless, D. K. The “MIF” stain-preservation technic for the identification of intestinal protozoa. Am. J. Trop. Med. 2:613–619, 1953.Google Scholar
  78. 78.
    Alger, N. A simple, rapid, precise stain for intestinal protozoa. Am. J. Clin. Pathol. 45:361–362, 1966.Google Scholar
  79. 79.
    Tompkins, V. N., Miller, J. K. Staining intestinal protozoa with iron-hematoxylinphosphotungstic acid. Am. J. Clin. Pathol. 17:755–758, 1947.PubMedGoogle Scholar
  80. 80.
    Gleason, N. N., Goldman, M., Carver, R. K. Size and nuclear morphology of Entamoeba histolytica and Entamoeba hartmanni trophozoites in culture and in man. Am. J. Hyg. 77:1–14, 1963.PubMedGoogle Scholar
  81. 81.
    Brooke, M. M. Laboratory diagnosis of amebiasis. Proc. VI Congr. Trop. Med. 3:369–384,1958.Google Scholar
  82. 82.
    Miyamoto, A. T., Thadepalli, H., Mishkin, F. S. 87Gallium images of amebic liver abscess. N. Engl. J. Med. 291:1363, 1974.PubMedGoogle Scholar
  83. 83.
    Matthews, A. W., Gough, K. R., Rhys Davies, E., et al. The use of combined ultrasonic and isotope scanning in the diagnosis of amoebic liver disease. Gut 14:50–53, 1973.PubMedCrossRefGoogle Scholar
  84. 84.
    Taylor, A. E. R., Baker, J. R. The Cultivation of Parasites In Vitro. Blackwell, Scientific Publishers, Oxford, 1968, pp. 377.Google Scholar
  85. 85.
    Diamond, L. S. Axenic cultivation of Entamoeba histolytica. Science 134:336–337, 1961.Google Scholar
  86. 86.
    Cleveland, L. R., Collier, J. The various improvements in the cultivation of Entamoeba histolytica. Am. J. Hyg. 12:606–613, 1930.Google Scholar
  87. 87.
    Balamuth, W. Improved egg yolk infusion for cultivation of Entamoeba histolytica and other intestinal protozoa. Am. J. Clin. Pathol. 16:380–384, 1946.PubMedGoogle Scholar
  88. 88.
    Nelson, E. C. Alcoholic extract medium for the diagnosis and cultivation of Endamoeba histolytica. Am. J. Trop. Med. 27:545–552, 1947.Google Scholar
  89. 89.
    McQuay, R. M. Charcoal medium for growth and maintenance of large and small races of Entamoeba histolytica. Am. J. Clin. Pathol. 26:1137–1141, 1956.PubMedGoogle Scholar
  90. 90.
    McQuay, R. M. Parasitologic studies in a group of furloughed missionaries: 1. Intestinal protozoa. Am. J. Trop. Med. Hyg. 16:154–160, 1967.PubMedGoogle Scholar
  91. 91.
    Robinson, G. L. The laboratory diagnosis of human parasitic amoebae. Trans. R. Soc. Trop. Med. Hyg. 62:285–294, 1968.PubMedCrossRefGoogle Scholar
  92. 92.
    Mahajan, R. C., Ganguly, N. K., Datta, D. V. Diagnosis of hepatic amoebiasis. Lancet 1:651, 1976.PubMedCrossRefGoogle Scholar
  93. 93.
    Craig, C. F. Observations upon the hemolytic, cytolytic and complement-binding properties of extracts of Endamoeba histolytica. Am. J. Trop. Med. 7:225–240, 1927.Google Scholar
  94. 94.
    Craig, C. F. Complement fixation in the diagnosis of infections with Endamoeba histolytica. Am. J. Trop. Med. 8:29–37, 1928.Google Scholar
  95. 95.
    Biagi, F. F., Buentello, L. Immobilization reaction for the diagnosis of amebiasis. Exp. Parasitoll 1:188–190, 1961.CrossRefGoogle Scholar
  96. 96.
    Keesel, J. F., Lewis, W. P., Pasquel, C. M., et al. Indirect hemagglutination and complement fixation tests in amebiasis. Am. J. Trop. Med. Hyg. 14:540–550, 1965.Google Scholar
  97. 97.
    Maddison, S. E., Powell, S. J., Elsdon-Dew, R. Application of serology to the epidemiology of amebiasis. Am. J. Trop. Med. Hyg. 14:554–557, 1965.Google Scholar
  98. 98.
    Morris, M. N., Powell, S. J., Eldson-Dew, R. Latex agglutination test for invasive amoebiasis. Lancet 1:1362–1363, 1970.PubMedCrossRefGoogle Scholar
  99. 99.
    Goldman, M. Evaluation of a fluorescent antibody test for amebiasis, using two widely differing ameba strains as antigen. Am. J. Trop. Med. Hyg. 15:694–700, 1966.PubMedGoogle Scholar
  100. 100.
    Krupp, I. M. Comparison of counterimmunoelectrophoresis with other serologic tests in the diagnosis of amebiasis. Am. J. Trop. Med. Hyg. 23:27–30, 1974.PubMedGoogle Scholar
  101. 101.
    Patterson, M., Healy, G. R., Shabot, J. M. Serologic testing for amoebiasis. Gastroenterology 78:136–141, 1980.PubMedGoogle Scholar
  102. 102.
    Juniper, K., Jr., Worrell, C. L., Minshew, M. C., et al. Serologic diagnosis of amebiasis. Am. J. Trop. Med. Hyg. 21:157–168, 1972.PubMedGoogle Scholar
  103. 103.
    Krupp, I., Antibody response in intestinal and extraintestinal amebiasis. Am. J. Trop. Med. Hyg. 19:57–62, 1970.PubMedGoogle Scholar
  104. 104.
    Milgram, E. A., Healy, G. R., Kagan, I. G. Studies on the use of the indirect hemagglutination test in the diagnosis of amebiasis. Gastroenterology 50:645–649, 1966.PubMedGoogle Scholar
  105. 105.
    Healy, G. R., Kraft, S. C. The indirect hemagglutination test for amebiasis in patients with inflammatory bowel disease. Am. J. Dig. Dis. 17:97–104, 1972.PubMedCrossRefGoogle Scholar
  106. 106.
    Healy, G. R., Kagan, I. G., Gleason, N. N. Use of the indirect hemagglutination test in some studies of seroepidemiology of amebiasis in the Western Hemisphere. Health Lab. Sci. 7:109–116, 1970.PubMedGoogle Scholar
  107. 107.
    Rogers, L. The rapid cure of amoebic dysentery and hepatitis by hypodermic injections of soluble salts of emetine. Br. Med. J. 1:1424–1425, 1912.PubMedCrossRefGoogle Scholar
  108. 108.
    Scott, F., Miller, M. J. Trials with metronidazole in amebic dysentery. J. Am. Med. Assoc. 211:118–120, 1970.CrossRefGoogle Scholar
  109. 109.
    Powell, S. J. Therapy of amebiasis. Bull. N. Y. Acad. Med. 47:469–477, 1971.PubMedGoogle Scholar
  110. 110.
    Powell, S. J., Elsdon-Dew, R. Evaluation of metronidazole and MK-910 in invasive amebiasis. Am. J. Trop. Med. Hyg. 20:839–841, 1971.PubMedGoogle Scholar
  111. 111.
    Griffin, F. M., Jr. Failure of metronidazole to cure hepatic amebic abscess. N. Engl. J. Med. 288:1397, 1973.PubMedCrossRefGoogle Scholar
  112. 112.
    Henn, R. M., Collin, D. B. Amebic abscess of the liver: Treatment failure with metronidazole. J. Am. Med. Assoc. 224:1394–1395, 1973.CrossRefGoogle Scholar
  113. 113.
    Stillman, A. E., Alvarez, V., Grube, D. Hepatic amebic abscess: Unresponsiveness to combination of metronidazole and surgical drainage. J. Am. Med. Assoc. 229:71–72, 1974.CrossRefGoogle Scholar
  114. 114.
    Weber, D. M. Amebic abscess of liver following metronidazole therapy. J. Am. Med. Assoc. 216:1339–1340, 1971.CrossRefGoogle Scholar
  115. 115.
    Pittman, F. E., Pittman, J. C. Amebic liver abscess following metronidazole therapy for amebic colitis. Am. J. Trop. Med. Hyg. 23:146–150, 1974.PubMedGoogle Scholar
  116. 116.
    Powell, S. J., Elsdon-Dew, R. Chloroquine in amoebic dysentery. Trans. R. Soc. Trop. Med. Hyg. 65:540, 1971.PubMedCrossRefGoogle Scholar
  117. 117.
    Pittman, F. E., Westphal, M. C. Optic atrophy following treatment with diiodohydroxyquin. Pediatrics 54:81–83, 1974.PubMedGoogle Scholar
  118. 118.
    Warning on diiodohydroxyquin. Med. Lett. Drugs Ther. 16:71–72, 1974.Google Scholar
  119. 119.
    Wolfe, M. S. Nondysenteric intestinal amebiasis: Treatment with diloxanide furoate. J. Am. Med. Assoc. 224:1601–1604, 1973.CrossRefGoogle Scholar
  120. 120.
    Is Flagyl dangerous? Med. Lett. Drugs Ther. 17:53–54, 1975.Google Scholar
  121. 121.
    Most, H. Treatment of common parasitic infections of man encountered in the United States: 2. N. Engl. J. Med. 287:698–702, 1972.PubMedCrossRefGoogle Scholar
  122. 122.
    Schwartz, D. E., Herrero, J. Comparative pharmacokinetic studies of dehydroemetine and emetine in guinea pigs using spectrofluorometric and radiometric methods. Am. J. Trop. Med. 14:78–83, 1965.Google Scholar
  123. 123.
    MacLeod, I. N., Powell, S. J., Wilmot, A. J. Hepatic amoebiasis. Br. Med. J. 2:827, 1966.CrossRefGoogle Scholar
  124. 124.
    Powell, S. J. Drug therapy of amoebiasis. Bull. W.H.O. 40:953–956, 1969.PubMedGoogle Scholar
  125. 125.
    Theron, P. Surgical aspects of amoebiasis. Br. Med. J. 2:123–126, 1947.PubMedCrossRefGoogle Scholar
  126. 126.
    Stein, D., Bank, S. Surgery in amoebic colitis. Gut 11:941–946, 1970.PubMedCrossRefGoogle Scholar
  127. 127.
    Hughes, F. B., Faehnle, S. T., Simon, J. L. Multiple cerebral abscesses complicating hepathopulmonary amebiasis. J. Pediatr. 86:95–96, 1975.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Herbert L. DuPont
    • 1
  • Larry K. Pickering
    • 2
  1. 1.Program in Infectious Diseases and Clinical MicrobiologyThe University of Texas Health Science Center Medical SchoolHoustonUSA
  2. 2.Pediatric Infectious Diseases Program in Infectious Diseases and Clinical MicrobiologyThe University of Texas Health Science Center Medical SchoolHoustonUSA

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