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Mononuclear Cells IgG Associated with Human Malignant Tissue

  • O. Tønder
  • R. Matre
  • F. Wesenberg
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 10)

Abstract

Surface receptors have become important as markers for the characterization and classification of mononuclear cells. Most attention has been focused on the receptors for sheep erythrocytes (E receptors), complement (C receptors), and the Fc region of the immunoglobulin molecule (Fc receptors). Rosette techniques are convenient for the detection of these receptors on cells in suspension. By applying the technique of hemadsorption to tissue sections, it is also possible to use the receptors as markers in studies of the topographic distribution of mononuclear cells in normal lymphoid organs, as well as in the characterization of neoplastic and inflammatory mononuclear cell infiltrates (Shevach et al., 1973; Jaffe et al., 1975; Stingl et al., 1977; Berard et al., 1978; Bjerke et al., 1978).

Keywords

Hairy Cell Leukemia Indicator Cell Sheep Erythrocyte Acta Pathol Mononuclear Cell Infiltrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Berard, C. W., Jaffe, E. S., Braylan, R. C., Mann, R. B., and Nanba, K., 1978, Immunologic aspects and pathology of the malignant lymphomas, Cancer 42: 911.PubMedCrossRefGoogle Scholar
  2. Bjerke, J. R., Krogh, H.-K., and Matre, R., 1978, Characterization of mononuclear cell infiltrates in psoriatic lesions, J. Invest. Dermatol. 71: 340.PubMedCrossRefGoogle Scholar
  3. Brubaker, D. B., and Whiteside, T. L., 1977, Localization of human T lymphocytes in tissue sections by a rosetting technique, Am. J. Pathol. 88: 323.PubMedGoogle Scholar
  4. Christensen, B. E., Jqsnsson, V., Matre, R., and Tonder, O., 1978, Traffic of T and B lymphocytes in the normal spleen, Scand. J. Haematol. 20: 246.PubMedCrossRefGoogle Scholar
  5. Cohen, D., Gurner, B. W., and Coombs, R. R. A., 1971, A phenomenon resembling opsonic adherence shown by disaggregated cells of the transmissible venereal tumour of the dog, Br. J. Exp. Pathol. 52: 447.Google Scholar
  6. Evans, R., 1976, Tumor macrophages in host immunity to malignancies, in: The Macrophage in Neoplasia ( M. Fink, ed.), pp. 27–42, Academic Press, New York.Google Scholar
  7. Jaffe, E. S., Shevach, E. M., Sussman, E. H., Frank, M., Green, I., and Berard, C. W., 1975, Membrane receptor sites for the identification of lymphoreticular cells in benign and malignant conditions, Br. J. Cancer 31: 107.Google Scholar
  8. Kaplan, M. E., and Clark, C., 1974, An improved rosetting assay for detection of human T lymphocytes, J. Immunol. Methods 5: 131.PubMedCrossRefGoogle Scholar
  9. Kerbel, R. S., and Pross, H. F., 1976, Fc receptor-bearing cells as a reliable marker for quantitation of host lymphoreticular infiltration of progressively growing solid tumors, Int. J. Cancer 18: 432.PubMedCrossRefGoogle Scholar
  10. Kerbel, R. S., Pross, H. F., and Elliot, E. V., 1975, Origin and partial characterization of Fc receptor-bearing cells found within experimental carcinomas and sarcomas, Int. J. Cancer 15: 918.PubMedCrossRefGoogle Scholar
  11. Lee, S.-T., and Paraskevas, F., 1978, Macrophage-T cell interactions. I. The uptake by T cells of Fc receptors released from macrophages, Cell. Immunol. 40: 141.PubMedCrossRefGoogle Scholar
  12. Matre, R., and Haugen, A., 1978, The placental Fey receptors studied using immune complexes of peroxidase, Scand. J. Immunol. 8: 187.PubMedCrossRefGoogle Scholar
  13. Matre, R., and Tonder, O., 1976, Complement receptors in human renal glomeruli, Scand. J. Immunol. 5: 917.CrossRefGoogle Scholar
  14. Matre, R., Talstad, I., and Haugen, A., 1977, Surface markers in non-phagocytic hairy cell leukemia, Acta Pathol. Microbiol. Scand. Sect. C 85: 406.Google Scholar
  15. Milgrom, F., Humphrey, L. J., Tonder, O., Yasuda, J., and Witebsky, E., 1968, Antibodymediated hemadsorption by tumor tissues, Int. Arch. Allergy Appl. Immunol. 33: 478.PubMedCrossRefGoogle Scholar
  16. Roubin, R., Césarini, J.-P., Fridman, W. H., Pavie-Fischer, J., and Peter, H. H., 1975, Characterization of the mononuclear cell infiltrate in human malignant melanoma, Int. J. Cancer 16: 61.PubMedCrossRefGoogle Scholar
  17. Russell, S. W., Doe, W. F., Hoskins, R. G., and Cochrane, C. G., 1976, Inflammatory cells in solid murine neoplasms. I. Tumor disaggregation and identification of constituent inflammatory cells, Int. J. Cancer 18: 322.PubMedCrossRefGoogle Scholar
  18. Shevach, E. M., Jaffe, E. S., and Green, I., 1973, Receptors for complement and immunoglobulin on human animal lymphoid cells, Transplant. Rev. 16: 3.PubMedGoogle Scholar
  19. Silveira, N. P. A., Mendes, N. F., and Tolnai, M. E. A., 1972, Tissue localization of two populations of human lymphocytes distinguished by membrane receptors, J. Immunol. 108: 1456.PubMedGoogle Scholar
  20. Stingl, G., Wolff, K., Diem, E., Baumgartner, G., and Knapp, W., 1977, In situ identification of lymphoreticular cells in benign and malignant infiltrates by membrane receptor sites, J. Invest. Dermatol. 69: 231.Google Scholar
  21. Tønder, O., and Krogh, H. K., 1980, Hemadsorption techniques for the in situ characterization of mononuclear cells in tissue, in: Autoimmunity in Psoriasis,(E. H. Beutner, S. Jablonska, and T. P. Chorzelski, eds.), Yearbook Medical Publishers, Chicago, in press.Google Scholar
  22. Tønder, O., and Thunold, S., 1973, Receptors for immunoglobulin Fe in human malignant tissues, Scand. J. Immunol. 2: 207.PubMedCrossRefGoogle Scholar
  23. Tønder, O., Morse, P. A., Jr., and Humphrey, L. J., 1974, Similarities of Fc receptors in human malignant tissue and normal lymphoid tissue, J. Immunol. 113: 1162.PubMedGoogle Scholar
  24. Tønder, O., Krishnan, E. C., Jewell, W. R., Morse, P. A., Jr., and Humphrey, L. J., 1976, Tumor Fc receptors and tumor-associated immunoglobulins, Acta Pathol. Microbiol. Scand. Sect. C 84: 105.Google Scholar
  25. Tønder, O., Krishnan, E. C., Morse, P. A., Jr., Jewell, W. R., and Humphrey, L. J., 1978, Localization of Fc receptors in human and rat malignant tissues, Acta Pathol. Microbiol. Scand. Sect. C 86: 173.Google Scholar
  26. Underwood, J. C. E., 1974, Lymphoreticular infiltration in human tumours: Prognostic and biological implications: A review, Br. J. Cancer 30: 538.PubMedCrossRefGoogle Scholar
  27. Wesenberg, F., 1978, Fcy receptors and IgG associated with human malignant tumours, Acta Pathol. Microbiol. Scand. Sect. C 86: 259.Google Scholar
  28. Wesenberg, F., and Tønder, O., 1978, Evidence for nonspecifically bound IgG in human tumours, Acta Pathol. Microbiol. Scand. Sect. C 86: 251.Google Scholar
  29. Witz, I. P., 1977, Tumor-bound immunoglobulins: In situ expressions of humoral immunity, Adv. Cancer Res. 25: 95.PubMedCrossRefGoogle Scholar
  30. Wood, G., and Gollahon, K. A., 1977, Detection and quantitation of macrophage infiltration into primary human tumors with the use of cell-surface markers, J. Natl. Cancer Inst. 59: 1081.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • O. Tønder
    • 1
  • R. Matre
    • 1
  • F. Wesenberg
    • 1
  1. 1.Broegelmann Research Laboratory for Microbiology and Department of Microbiology The Gade InstituteUniversity of BergenBergenNorway

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