Evidence for Mononuclear Phagocytes in Solid Neoplasms and Appraisal of Their Nonspecific Cytotoxic Capabilities

  • Stephen W. Russell
  • G. Yancey Gillespie
  • Judith L. Pace
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 10)


After years of being viewed as little more than scavengers, mononuclear phagocytes are now more properly regarded as cells with a multiplicity of functions. One of these, tumor cell killing, recently has attracted particular interest. Both antigenically specific and nonspecific effects have been reported (for reviews, see Evans and Alexander, 1976; Hibbs, 1976; and Keller, 1976). Of the two, nonspecific killing has been the most extensively studied, with a number of candidates for the cytolytic mechanism(s) now under consideration (Hibbs, 1974a; Bucana, et al.,1976; Ferluga, et al., 1978; Schorlemmer, et al., 1978; Currie, 1978; Adams, 1978). The process is nonphagocytic in its nature, either contact or extremely close juxtaposition of the target and effector cells is required, and only tumor cells appear to be susceptible to killing.


Mononuclear Phagocyte Cytolytic Activity Tumor Target Cell Macrophage Content Tumor Tissue Section 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Stephen W. Russell
    • 1
  • G. Yancey Gillespie
    • 1
  • Judith L. Pace
    • 1
  1. 1.Department of Pathology and The Cancer Research CenterUniversity of North Carolina School of MedicineChapel HillUSA

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