Separation and Characteristics of Tumor-Infiltrating Lymphocytes in Man

  • E. Klein
  • F. Vánky
  • U. Galili
  • B. M. Vose
  • M. Fopp
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 10)


During the initial phase of tumor immunology, when experiments were conducted with syngeneic systems, without the involvement of reactivities against histocompatibility antigens, the accumulation of important information was explosive. As usual with accumulating knowledge, the number of unanswered questions increased. It may seem disappointing that in spite of intense activity, progress has been relatively slow in two important areas that deal with the following questions: (1) Are there any immune parameters in man which can be exploited for diagnosis or antitumor response? (2) What is the relevance of any in vitro-detected tumor-related reacticity for the events associated with tumor development in vivo?


Squamous Cell Carcinoma Human Serum Albumin Reactivity Index Viable Tumor Cell Normal Human Serum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



autologous tumor stimulation


autologous lymphocyte cytotoxicity


tumor-infiltrating lymphocytes


peripheral blood lymphocytes






natural killer


natural attachment


balanced salt solution


phosphate-buffered saline


normal human serum


human serum albumin


fetal calf serum


bovine serum albumin




sheep red blood cells


cells with rosettes of SRBC


surface immunoglobulin


deoxyribonucleic acid




mixed lymphocyte culture


mitomycin C


counts per minute


reactivity index




Epstein-Barr virus




nasopharyngeal carcinoma


fluorescein isothiocyanate


delayed cutaneous hypersensitivity


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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • E. Klein
    • 1
  • F. Vánky
    • 1
  • U. Galili
    • 1
  • B. M. Vose
    • 1
  • M. Fopp
    • 1
  1. 1.Department of Tumor Biology Karolinska Institute RadiumhemmetKarolinska SjukhusetStockholm 60Sweden

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