Host Cell Analysis of a Rapidly Metastasizing Mouse Tumor and Derived Low-Metastatic Variant Lines

  • R. S. Kerbel
  • R. R. Twiddy
  • P. Frost
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 10)


Pathologists have been aware for decades that malignant tumors can become infiltrated with significant numbers of nonmalignant stromal and lymphoreticular host cells. For certain types of malignancies, e.g., breast carcinoma, it has been claimed that the prognosis may correlate with the extent of host cell infiltration (reviewed by Underwood, 1974, and Ioachim, 1976). However, it is obvious that the light microscope has certain serious limitations when it comes to screening neoplasms for host cells. It cannot, for example, discriminate between a T or a B lymphocyte, nor can it be used as a reliable tool, as Alexander has stressed (1975), to detect certain kinds of host cells, in particular, macrophages. This fact, combined with the increasing awareness of the existence of functional subclasses of lymphocytes and macrophages (e.g., helper, killer, and suppressor T-cell subclasses), has made quantitative and qualitative studies of host cell infiltration an important feature of current tumor biology research.

Table I.

Examples of Descriptive Studies of Intratumor Lymphoreticular Host Cells


Key findings


Analysis of tumors of varying immunogenicity

Highly immunogenic experimental tumors contain more host cells and macrophages than poorly immunogenic tumors

K. Moore and Moore (1977), Eccles and Alexander (1975)

Analysis of primary versus serially transplanted chemically induced tumors

Relative host cell content of all cell types, including macrophages, drops with increasing sequential passage

Kerbel and Pross (1976)

Analysis of progressing versus regressing tumors

Host cells can make up predominant population in spontaneously regressing tumors but only a minor component in same type of tumor growing progressively

Haskill et al. (1975)


Host Cell Tumor Line Single Cell Cloning Host Cell Response Macro Phage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • R. S. Kerbel
    • 1
  • R. R. Twiddy
    • 1
  • P. Frost
    • 2
  1. 1.National Cancer Institute of Canada Research Group, Division of Cancer Research, Department of PathologyQueen’s UniversityKingstonCanada
  2. 2.Department of Immunology and MicrobiologyWayne State UniversityDetroitUSA

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