Growth-Hormone-Secreting Pituitary Adenomas
Acromegaly is a rare endocrinopathy that is estimated to occur with a frequency of one in 5000–15,000 patients.1 The term, derived from the Greek akron (extremity) and megale (great), was first used by Marie2 in 1886 to describe two patients with a syndrome in which hypertrophy of the extremities was the most striking clinical feature. His clinical description delineated the classic features of this condition, viz., marked enlargement of the hands and feet, prognathism, macroglossia, thickened skin associated with headache, joint pain, and lethargy. Although a relationship to the pituitary was postulated, Marie interpreted autopsy findings of a pituitary tumor in acromegaly as evidence of adenohypophyseal insufficiency (for a historical review, see Lawrence. 3 ). It was Harvey Cushing4 who in 1909 first used the term ‘‘hyperpituitarism” in relation to acromegaly, and his concept was provided with a firm scientific basis following the demonstration by Evans and Long that gigantism could be produced in rats by injection of a pituitary gland extract.
KeywordsPituitary Adenoma Pituitary Tumor Carpal Tunnel Trigeminal Neuralgia Acromegalic Patient
Unable to display preview. Download preview PDF.
- 1.N.P. Christy, Acromegaly, in: Cecil-Loeb Textbook of Medicine (P.B. Beeson and W. McDer-mott, eds.), Vol. 2, 12th ed., p. 1277, W.B. Saunders, Philadelphia, 1967.Google Scholar
- 2.P. Marie, Sur deux cas d’acromegalic; hypertrophie singulière, non congénitale, des extrémités supérieures, inférieurs et céphalique, Rev. Med. [Paris] 6:297, 1886.Google Scholar
- 5.W.H. Daughaday, The adenohypophysis, in: Textbook of Endocrinology, 5th ed. (R.H. Williams, ed.), pp. 31–77, W.B. Saunders, Philadelphia, 1974.Google Scholar
- 7.F. Drimmer, There were giants in the earth, in: Very Special People, pp. 269–322, Amjon Publishers, New York, 1973.Google Scholar
- 21.M. Muggeo, R.S. Bar, Roth, J., Two abnormalities in insulin binding to its receptor in the insulin resistance of acromegaly, Clin. Res. 26:310a, 1978.Google Scholar
- 27.L.A. Frohman, M. Szabo, M.E. Stachura, S. Zafar, R.C. Mellinger, and G. Fine, Growth hormone—releasing activity in an extract of a bronchial carcinoid associated with acromegaly, Clin. Res. 26:702A, 1978.Google Scholar