Galactorrhea Syndromes

  • Bruce J. Biller
  • Aubrey BoydIII
  • Mark E. Molitch
  • Kalmon D. Post
  • Samuel M. Wolpert
  • Seymour Reichlin


With the advent of prolactin radioimmunoassay1–4 and the development of sophisticated radiological techniques for visualization of the pituitary fossa,5 it has become apparent that prolactin-producing pituitary adenomas are the most common pituitary disease seen in clinical practice.6 Patients with prolactinomas often present with galactorrhea as the cardinal symptom,7 and it has therefore become a major diagnostic dilemma to distinguish those patients who harbor adenomas from those with galactorrhea due to other causes. This chapter is designed to: (1) delineate and characterize the subgroup of galactorrhea patients with pituitary adenomas; (2) provide detailed, long-term follow-up of galactorrhea syndromes in order to define their natural history more precisely; (3) determine the influence of elevated prolactin levels on pituitary, adrenal, and ovarian function; and (4) study the etiological factors involved in galactorrhea. Results of initial study of 25 galactorrhea patients have recently been reported by our group.8 We have now had the opportunity to extend the study in a more detailed fashion to an additional 45 patients. This larger sample of 70 galactorrhea patients provided a wider variety of clinical expression of this syndrome, led to revision of standards of prolactin values associated with tumors, and modified our earlier interpretations of the significance of stimulation tests. These findings are analyzed and compared with studies of other investigators.9–12


Luteinizing Hormone Pituitary Adenoma Pituitary Tumor Prolactin Secretion Secondary Amenorrhea 
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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Bruce J. Biller
    • 1
    • 2
  • Aubrey BoydIII
    • 1
    • 2
  • Mark E. Molitch
    • 1
    • 2
  • Kalmon D. Post
    • 1
    • 3
  • Samuel M. Wolpert
  • Seymour Reichlin
    • 1
    • 2
  1. 1.Tufts University School of MedicineBostonUSA
  2. 2.Department of Medicine, Division of EndocrinologyTufts-New England Medical Center HospitalBostonUSA
  3. 3.Department of NeurosurgeryTufts-New England Medical Center HospitalBostonUSA

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