Immunologic Effects of UV Radiation and Their Role in Photocarcinogenesis

  • Margaret L. Kripke


The intersection of immunology and photocarcinogenesis in experimental research is a very recent phenomenon. Although the immunologic aspects of other types of carcinogenesis and the role of the immune system in light-induced dermatologic abnormalities have been under investigation for some time, the history of investigations on the role of the immune system in photocarcinogenesis extends back for only about five years. For this reason, the experimental studies performed to date are limited in both scope and number. Thus, the review of this topic relies heavily on studies performed in my laboratory for reasons of necessity, rather than negligence. Justification for reviewing such a recent area of experimentation is provided by the fact that these studies, which seem to be of increasing interest to photobiologists, are reported in various oncology and immunology journals and are oriented toward specialists in these disciplines. However, such a review cannot be expected to provide much perspective on the application of this work to problems of human skin cancer, since the potential of this approach has not yet been fully explored. At best, it could provide a summary of the state of this field and serve to identify some of the questions that remain unanswered.


Tumor Antigen Suppressor Cell Immunologic Effect Irradiate Mouse Tumor Challenge 


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Margaret L. Kripke
    • 1
  1. 1.Cancer Biology ProgramNCI Frederick Cancer Research CenterFrederickUSA

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