Neuroamine Condensations in Human Subjects
Non-enzymatic reactions have held relatively little appeal for biomedical researchers who work with mammalian tissues and eucharyotic cells, and understandably so. When confronted with the splendid array and catalytic efficiencies of enzymes, it can be argued that “uncatalyzed” reactions should be rare in occurrence and probably minor in significance. Accumulated studies indicate however, that presumably non-enzymatic reactions — in particular, bimolecular condensations between amino compounds and aldehydes or α-keto acids — are not as uncommon as assumed. In part, this revelation is due to the new and highly sensitive chromatography methods which have developed recently (Collins, 1977). And other studies, neuropharmacological, enzymological, and behavioral in nature, demonstrate that certain condensation “products” are clearly not insignificant or innocuous agents.
KeywordsHigh Performance Liquid Chromatography Schiff Base Condensation Product Pyridoxal Phosphate Phenylpyruvic Acid
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- COLLINS, M.A., 1977, Identification of isoquinoline alkaloids during alcohol intoxication, in Alcohol and Opiates: Neurochem. Behav. Mech. (Ed. K. Blum), Acad. Press, N.Y., 155–166.Google Scholar
- GALLOWAY, M.P. BURKE, W.J., KOSLOFF, A., LIEBERMAN, D.L., MITCHELL, J., and COSCIA, C.J., 1978, Effect of a class of naturally-occurring tetrahydroisoquinolines on catecholamine metabolism in rat adrenal medulla; Importance of methylation. Neurosci. Abst. 4, 315.Google Scholar
- HSIA, Y.E., 1976, Disorders of amino acid metabolism, in Basic Neurochemistry (Eds. Siegel, G., Albers, R.W., Ratzman, R, and Agranoff, B.), Little, Brown and Co., 2nd Ed., 500–541.Google Scholar
- LASAX, A.J.M., COSCIA, C.J. and CICERO, T.J., 1978, Inhibition of catecholamine-uptake by naturally-occurring tetrahydroisoquino- lines and its possible relevance to both L’-DOPA chemotherapy in Parkinsonism and to phenylketonuria. Neurosci. Abst., 4, 428.Google Scholar
- MEYERSON, L.R., GEORGE, B., ABEL, M., PHILIPS, H., DAVIS, V.E, and CLEMENT-CORMIER, Y.C., 1978A, Characterization of striatal 3H-apomorphine and 3H-spiroperidol binding and dopamine- sensitive adenylate cyclase activity utilizing protoberberine alkaloids. Neurosci, Abst., 4, 516.Google Scholar
- NIJM, W.P., BORGE, G.F., ORIGITANO, T., TEAS, G., GOLDFARB, C. and COLLINS, M.A., 1978, Lack of evidence for sustained blood acetaldehyde concentrations during alcohol detoxification. Res. Comm. Chem. Path. Pharmacol., 20, 178–190.Google Scholar
- NIJM, W.P., RIGGIN, R., TEAS, G., KISSINGER, P.T., BORGE, G., and COLLINS, M.A., 1977, Urinary dopamine-related tetrahydroiso- quinolines: Studies of alcoholics and non-alcoholics. Fedn. Proc., 36, 334.Google Scholar
- ROBBINS, J.H., 1968, Possible alkaloid formation in alcoholism and other diseases. Clin. Res., 16, 554.Google Scholar
- SANDLER, M., 1973, The DOPA effect: Possible significance of transamination and tetrahydroisoquinoline formation. Adv. Neurol. 2, 255–264.Google Scholar