Neuropsychological Investigation of Brain Lesion Localization in Alcoholism

  • Gerald Goldstein
  • Carolyn Shelly
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)


While a variety of behavioral deficits have been associated with chronic alcoholism, there is still an incomplete understanding of the relationship between these deficits and their basis in central nervous system changes. One aspect of the problem has to do with structural changes in localized areas of the brain. It has been proposed that certain brain structures are particularly sensitive to the effects of alcoholism and deteriorate more readily than do other structures. For example, the effects of alcohol on cerebellar function are well known. With regard to the cerebral hemispheres, however, controversy remains.


Brain Damage Chronic Alcoholism Discriminant Function Analysis Chronic Alcohol Abuse Frontal Lobe Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Blass, J. P. & Gibson, G. E. Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. The New England Journal of Medicine, 1977, 297, 1367–1370.PubMedCrossRefGoogle Scholar
  2. Goldstein, G. The use of clinical neuropsychological methods in the lateralisation of brain lesions. In Diamond, S. J. & Beaumont, J. G. (Eds.) Hemisphere function in the human brain. London:Elek Science, 1974.Google Scholar
  3. Goldstein, G. & Shelly, C. H. Statistical and normative studies of the Halstead neuropsychological test battery relevant to a neuropsychiatriac hospital setting. Perceptual and Motor Skills, 1972, 34, 603–620.PubMedCrossRefGoogle Scholar
  4. Goldstein, K. The significance of the frontal lobes for mental performance. Journal of Neurology and Psychopathology, 1936, 17, 27.PubMedCentralPubMedCrossRefGoogle Scholar
  5. Milner, B. Effects of different brain lesions on card sorting:the role of the frontal lobes. Archives of Neurology, 1963, 9 90–100.CrossRefGoogle Scholar
  6. Milner, B. Some effects of frontal lobectomy in man. In Warren, J. M. & Akert, K. (Eds.) The frontal granular cortex and behavior. New York: McGraw-Hill, 1964.Google Scholar
  7. Reitan, R. M. A research program on the psychological effects of brain lesions in human beings. In Ellis, N. R. (Ed.) International review of research in mental retardation.(Vol. 1) New York: Academic Press, 1966.Google Scholar
  8. Reitan, R. M. & Davison, L.A. Clinical neuropsychology: Current status and applications. Washington, D.C.: V. H. Winston & Sons, 1974.Google Scholar
  9. Russell, A., Neuringer, C., & Goldstein, G. Assessment of brain damage: A neuropsychological key approach. New York: Wiley-Interscience, 1970.Google Scholar
  10. Tarter, R. Brain damage associated with chronic alcoholism. Diseases of the Nervous System. 1975a, 36, 185–187.PubMedGoogle Scholar
  11. Tarter, R. Psychological deficit in chronic alcoholics: A review. International Journal of the Addictions. 1975b, 10, 327–368.Google Scholar
  12. Tarter, R. E. Neuropsychological investigations of alcoholism. In Goldstein, G. & Neuringer, C. (Eds.) Empirical studies of alcoholism. Cambridge, Mass.: Ballinger, 1976.Google Scholar
  13. Teuber, H.-L., Battersby, W. S. & Bender, M. B. Changes in visual searching performance following cerebral lesions. American Journal of Physiology, 1949, 159, 592.Google Scholar
  14. Teuber, H.-L. The riddle of frontal lobe function in man. In Warren, J. M. & Akert, K. (Eds.) The frontal granular cortex and behavior. New York: McGraw-Hill, 1964.Google Scholar
  15. Victor, M., Adams, R. D. & Collins, G. H. The Wernicke-Korsakoff syndrome. Philadelphia: F. A. Davis, 1971.Google Scholar
  16. Wheeler, L., Burke, C. J. & Reitan, R. M. An application of discriminant functions to the problem of predicting brain damage using behavioral variables. Perceptual and Motor Skills, 1963, 16, 417–440PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Gerald Goldstein
    • 1
  • Carolyn Shelly
    • 1
  1. 1.Highland DriveVA Medical CenterPittsburghUSA

Personalised recommendations