Multivariate Approach to Alcoholic Cognitive Function

  • Althea M. I. Wagman
  • Benjamin Kissin
  • Richard P. Allen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)


There is no doubt that ingestion of moderate to large amounts of alcohol disrupts a broad spectrum of behavior systems. Although very few studies have addressed the question of residual dysfunction following the termination of alcohol consumption, the evidence is becoming stronger that chronic alcohol consumption induces characteristic changes in brain morphology for at least a proportion of patients. Therefore, behavior systems which are dependent upon the integrity of these altered neural systems would be characteristically disrupted.


Concept Formation Slow Wave Sleep Chronic Alcoholic Problem Drinking Multivariate Approach 
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  1. Allen, R.P. Gross, M.M. Personal communication, 1976.Google Scholar
  2. Bergman, H. Computed tomography of the brain and neuropsychological assessment of alcoholic patients. This volume.Google Scholar
  3. Bertera, J.H. Parsons, O.A. Impaired visual search in alcoholics. Alcoholism; Clinical & Experi mental Research, 1978, 2, 9–14.CrossRefGoogle Scholar
  4. Butters, N., Cermak, L. & Adinolfi, A. Some comparisons of the memory and visuoperceptive deficits of chronic alcoholics and patients with Korsakoff’s disease. Alcoholism, 1978, 1 98–106.Google Scholar
  5. Carlen, P.L., Wortzman, G., Holgate, R.C., Wilkinson, D.A. Rankin, J.G. Reversible cerebral atrophy in recently abstinent chronic alcoholics easured by computed tomography scans. Science, 1978, 200, 1076–1078.PubMedCrossRefGoogle Scholar
  6. Chandler, B.C. & Parsons, O.A. Altered hemispheric function under alcohol. Journal of Studies on Alcohol, 1977, 38, 3. 381–391PubMedGoogle Scholar
  7. Courville, C.B. Effects of alcohol on the nervous system of man Los Angeles: San Lucas Press, 1955.Google Scholar
  8. Davies, A.D.M. Age and the Memory For-Designs Test. British Journal of Sociology & Clinical Psychology, 1967, 6, 228–233.CrossRefGoogle Scholar
  9. DeRenzi, E., Faglioni, P.,& Previdi, P. Spatial memory and hemispheric locus of lesion. Cortex, 1977, 13, 424–433.CrossRefGoogle Scholar
  10. Diesfeldt, H.F.A. The distinction between long-term and short-term memory in senile dementia: An analysis of free recall and delayed recognition. Neuropsychologla, 1978, 16, 115–119.CrossRefGoogle Scholar
  11. Donovan, D.M., Queisser, H.R. & O’Leary, M.R. Group Embedded Figures Test performance as a predictor of cognitive impairment among alcoholics. The International Journal of the Addictions, 1976, 11,5 S, 725–739.Google Scholar
  12. Drewe, E.A. The effect of type and area of brain lesion on Wisconsin Card Sorting Test performance. Cortex, 1974, 10, 159–170.PubMedCrossRefGoogle Scholar
  13. Epstein, P.S., Pisani, V.D. & Fawcett, J.A. Alcoholism and cerebral atrophy. Alcoholism, 1978, 1, 83–91.Google Scholar
  14. Graham, F.K. & Kendall, B.S. Memory-For-Designs Test: Revised general manual. Perceptual & Motor Skills, 1960, 11, 147–188.Google Scholar
  15. Gross, M.M., Goodenough, D.R., Hastey, J.M., Rosenblatt, S.M. & Lewis, E. Sleep disturbances in alcohol intoxication and withdrawal. In N.K. Mello S J.H. Mondelson (Eds.) Recent advances in studies of alcoholism. Washington, D.C.: Ü.S. Government Printing Office, 1971.Google Scholar
  16. Gross, M.M. & Hastey, J.M. The relation between baseline slow wave sleep and the slow wave sleep response to alcohol in alcoholics. In M.M. Gross (Ed.) Alcohol intoxication and withdrawal: Experimental studies II. Advances in Experimental Medicine and Biology, Vol.(59). New York: Plenum Press, 1975.Google Scholar
  17. Gross, M.M., Hastey, J.M., Lewis, E. & Young, N. Slow wave sleep and carry-over of functional tolerance and physical dependence in alcoholics. In M.M. Gross (Ed.) Alcohol intoxication and withdrawal: Experimental Studies II. Advances in Experimental Medicine and Biology (Vol. 59). New York: Plenum Press, 1975.Google Scholar
  18. Gross, M.M., Kissin, B. & Feuer, L. Gross assessment of alcohol withdrawal: II. Clinical significance of factors. Archives of General Psychiatry, 1978, in press.Google Scholar
  19. Gudeman, H.W., Craine, J.F., Golden, C.J. & McLaughlin D. Higher cortical dysfunction associated with long term alcoholism. International Journal Neuroscience, 1977, 8, 33–40.CrossRefGoogle Scholar
  20. Halstead, W.C. Preliminary analysis of grouping behavior in patients with cerebral injury by the method of equivalent and non-equivalent stimuli. American Journal of Psychiatry, 1940, 96, 1263–1291.Google Scholar
  21. Horvatli, T.B. Clinical spectrum and epidemiological features o£ alcoholic dementia. In J.G. Rankin (Ed.) Alcohol) drugs and brain damage. Toronto: Alcoholism and Drug Addiction Research Foundation, 1975.Google Scholar
  22. Johnson, L.C., Naitoh, P., Moses, J. & Lubin, S. Interaction of REM deprivation and Stage 4 deprivation with total sleep loss: Experiment 2. Psychophysiology, 1974, 11, 147–159.PubMedCrossRefGoogle Scholar
  23. Jones, B.M. Verbal and spatial intelligence in short and long term alcoholccs. Journal of Nervous and Mental Disease, 1971, 153, 292–297.PubMedCrossRefGoogle Scholar
  24. Klisz, D. Personal communication, 1977.Google Scholar
  25. Malerstein, A.J. Beiden, E. WAIS, SILS, and PPVT in Korsakoffs syndrome. Archives of General Psychiatry, 1968, 19, 743–750.PubMedCrossRefGoogle Scholar
  26. Milner, B. Effects of different brain lesions on card sorting. The role of the frontal lobes. Archives of Neurology, 1963, 9, 90–100.CrossRefGoogle Scholar
  27. Nebes, R.D. Hemispheric specialization in commissuorotomized man. Psychological Bulletin, 1974, 81, 1–14.PubMedCrossRefGoogle Scholar
  28. Parker, E.S. & Noble, E.P. Alcohol consumption and cognitive functioning in social drinkers. Journal of Studies on Alcohol, 1977, 38, 7, 1224–1232PubMedGoogle Scholar
  29. Parsons, O., Tarter, R. & Edelberg, R. Altered motorcontrol in chronic alcoholics. Journal of Abnormal Psychology, 1972, 80, 3, 308–314PubMedCrossRefGoogle Scholar
  30. Porjesz, B. & Begleiter, H. Visual evoked potentials and brain dysfunction in chronic alcoholics. In Evoked brain potentials and behavior, in press.Google Scholar
  31. Porjesz, B. & Begleiter, H. Alcohol and bilateral evoked brain potentials. In M.M. Gross (Ed.) Alcohol intoxication and withdrawal: Experimental studies II. Advances in Experimental Medicine and Biology (Vol. 59). New York: Plenum Press, 1975.Google Scholar
  32. Raven, J.C. Standard Progressive Matrices. New York: The Psychological Corporation, 1958.Google Scholar
  33. Rechtschaffen, A. & Kales, A. A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects. Washington, D.C., U.S. Government Printing Office, 1968.Google Scholar
  34. Rosvold, H.E. § Mishkin, M. Non-sensory effects of frontal lesions on discrimination learning and performance. In J.F. Delafresnaye (Ed.) Brain mechanisms and learning. Oxford: Blackwell Scientific Publications, 1961.Google Scholar
  35. Tarter, R.E. An analysis of cognitive deficits in chronic alcoholics. The Journal of Nervous and Mental Disease, 1973, 157, 2, 138–147.PubMedCrossRefGoogle Scholar
  36. Tarter, R.E. § Parsons, O.A. Conceptual shifting in chronic alcoholics. Journal of Abnormal Psychology, 1971, 77, 71–75.PubMedCrossRefGoogle Scholar
  37. Teuber, H.L. The frontal lobes and their function: Further observations on rodent, carnivores, subhuman primates, and man. International Journal of Neurology, 1966, 5, 282–300Google Scholar
  38. Wagman, A.M.I. & Allen, R.P. Effects of alcohol ingestion and abstinence on slow wave sleep of alcoholics. In M.M. Gross (Ed.) Alcohol intoxication and withdrawal; Experimental Studies II. Advances in experimental medicine and biology (Vol. 59). New York: Plenum Press, 1975.Google Scholar
  39. Wagman, A.M.I., Allen, R.P., Funderburk, F. & Upright, D. EEG measures of functional tolerance to alcohol. Biological Psychiatry, in press.Google Scholar
  40. Wilkinson, A Relation of neuropsychological test performance to brain morphology measured by CT scan his volume.Google Scholar
  41. Yules, R.B., Friedman, D.X. & Chandler, K.A. The effect of ethyl alcohol on man’s electroencephalographic sleep cycles. Electroencephalography & Clinical Neurophysiology, 1966, 20, 109–111.CrossRefGoogle Scholar
  42. Yules, R.B., Lippman, M.E. & Friedman, D.X. Alcohol administration prior to sleep: The effect on EEG sleep stages. Archives of General Psychiatry, 1967, 16, 94–97.PubMedCrossRefGoogle Scholar
  43. Zarcone, V., Barchas, J., Hoddes, E., Montplaisir, J, Sack, R. 5 Wilson, R. Experimental ethanol ingestion: Sleep variables and metabolites Of dopamine and serotonin in the cerebrospinal fluid. In M.M. Gross (Ed.) Alcohol intoxication and withdrawal: Experimental Studies II. Advances in Experimental Medicine and Biology, (Vol. 59). New York: Plenum Press, 1975.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Althea M. I. Wagman
    • 1
  • Benjamin Kissin
    • 1
  • Richard P. Allen
    • 1
  1. 1.Maryland Psychiatric Research Center, Downstate Medical CenterBaltimore City HospitalsUSA

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