Calcium Receptor Binding in Synaptic Membranes of ICR, C57, DBA Mice After Ethanol Exposure
Ethanol interaction with nerve membranes is believed to produce localized changes in structural and functional components affecting neurotransmitter activity, enzymes and ion transport. It is unclear as to what happens mechanistically but repeated exposure of the membranes leads to a state of tolerance and if the ethanol concentrations and duration of exposure are severe enough, physical dependence may be elicited upon drug withdrawal. Although the sequence of events and total number of processes involved are unknown, most investigators agree upon initial membrane fluidity or the fluidizability of membrane components (1,2,3). Implicit in these assumptions is the fact that ethanol must act to alter structural components in the membrane which directly or indirectly influence membrane function. Indeed both lipid and protein components have been shown to be altered after ethanol exposure (4,5,6).
KeywordsEthanol Exposure Synaptic Membrane Scorpion Venom Synaptic Plasma Membrane Maximal Binding Capacity
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