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Requirements for an Ideal Alcohol Antagonist

  • Chapter
Biological Effects of Alcohol

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 126))

Abstract

There are, in the broadest terms, several types of alcohol antagonists which we can talk about:

  1. 1.

    blockers of tolerance or dependence production

  2. 2.

    blockers of withdrawal symptoms

  3. 3.

    antagonists of alcohol drinking or preference

  4. 4.

    blockers (“reversers”) of acute intoxication, also known as amethystic agents.

Supported by PHS Grant AA-01417.

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References

  • Allen, L.E., Ferguson, H.C., and McKinney, G.R., A survey of selected drugs on behavior performance in ethanol-treated rats, Eur. J. Pharmacol. 15: 371–374 (1971).

    Article  CAS  PubMed  Google Scholar 

  • Ahlenius, S., Carlsson, A., Engel, J., Svensson, T., and Södersten, P., Antagonism by alpha methyltyrosine of the ethanol-induced stimulation and euphoria, Clin. Pharmacol. Ther. 14: 586–591 (1973).

    CAS  PubMed  Google Scholar 

  • Ahlenius, S., Brown, R., Engel, J., Svensson, T.H., and Waldeck, B., Antagonism by nialamide of the ethanol-induced locomotor stimulation in mice, J. Neur. Trans. 35: 175–178 (1974).

    Article  CAS  Google Scholar 

  • Blum, K., Wallace, J.E., Ryback, R.S., and Geller, I., Diethanolamine: A possible weak agonist-antagonist to ethanol, Eur. J. Pharmacol. 19: 218–222 (1972).

    Article  CAS  PubMed  Google Scholar 

  • Blum, K., Wallace, J.E., and Friedman, R.N., Reduction of acute alcoholic intoxication by a amino acids: glycine and serine. Life Sci. 14: 557–565 (1974).

    Article  CAS  PubMed  Google Scholar 

  • Bourrinet, P., Etude experimentale de I’influence de I’alcoolisation aiguë et chronique sur I’activite des medicaments. Rev. Alcoolisme 10: 186–198 (1964).

    Google Scholar 

  • Breese, G.R., Cott, J.M., Cooper, B.R., Prange, A.J., and Lipton, M.A., Antagonism of ethanol narcosis by thyrotropin releasing hormone. Life Sci. 14: 1053–1063 (1974).

    Article  CAS  PubMed  Google Scholar 

  • Breglia, R.J., Ward, C.O., Jarowski, C.I., Effect of selected amino acids on ethanol toxicity in rats, J. Pharm. Sci. 62: 49–55 (1973).

    Article  CAS  PubMed  Google Scholar 

  • Brown, S.S., Forrest, J.A.H., and Roscoe, P., A controlled trial of fructose in the treatment of acute alcoholic intoxication. Lancet 898–900 (Oct. 28, 1972).

    Google Scholar 

  • Erickson, C.K. and Burnam, W.L., Cholinergic alteration of ethanol-induced sleep and death in mice, Ag. Actions 2: 8–13 (1971).

    Article  CAS  Google Scholar 

  • Erickson, C.K. and Matchett, J.A., Correlation of brain amine changes with ethanol-induced sleep-time in mice, in: Alcohol Intoxication and Withdrawal II, Gross, M.M., ed. Adv. Exptl. Med. Biol., Plenum Press, New York (1975), vol. 59, pp. 419–430.

    Google Scholar 

  • Erickson, C.K. and Chai, K.J. Cholinergic modification of ethanol-induced electroencephalographic synchrony in the rat, Neuropharmacol. 15: 39–43 (1976).

    Article  CAS  Google Scholar 

  • Erickson, C.K., Tyler, T.D., and Harris, R.A., Ethanol: modification of acute intoxication by divalent cations. Science 199: 1219–1221 (1978).

    Article  CAS  PubMed  Google Scholar 

  • Forney, R.B. and Hughes, F.W., Effect of caffeine and alcohol on performance under stress of audiofeedback. Quart. J. Studies Alc. 26: 206–212 (1965).

    CAS  Google Scholar 

  • Frankel, D., Kalant, H., Khanna, J.M., and LeBlanc, A.E., Interaction of propranolol and phentolamine with ethanol in the rat. Can. J. Physiol. Pharmacol. 54: 622–625 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Frommel, E. and Seydoux, J., De I’effet de I’éthanol sur I’encéphale. Bilan des tests dits de neuropharmacologie chez I’animal. Helv. Physiol. Pharmacol. Acta 22: 34–38 (1964).

    CAS  PubMed  Google Scholar 

  • Geller, I., Campbell, N.D., and Blum, K., Protection against acute alcoholic intoxication with diethanolaminerutin, Res. Commun. Chem. Pathol. Pharmacol. 1: 383–394 (1970).

    CAS  PubMed  Google Scholar 

  • Gold, H. and Travell, J., Strychnine in poisoning by alcohol, J. Pharmacol. Exptl. Ther. 52: 345–354 (1934).

    CAS  Google Scholar 

  • Greenberg, R.E., Prevention of alcohol-induced cortical depression with stimulants and tertiary amines. Quart. J. Studies Alc. 28: 1–10 (1967).

    CAS  Google Scholar 

  • Harris, R.A. and Erickson, C.K., Alteration of ethanol effects by opiate antagonists, Curr. Alcoholism (in press, 1978).

    Google Scholar 

  • Hayashida, K. and Smith, A.A., Reversal by Sotalol of the respiratory depression induced in mice by ethanol, J. Pharm. Pharmac. 23: 718–719 (1971).

    Article  CAS  Google Scholar 

  • Hillbom, M.E., Linkola, J., Nikander, P., and Wallgren, H., Effects of Pyrithioxine, EMD 17246 and Diethanolamine-Rutin on acute alcoholic intoxication in rats. Acta Pharmacol. Toxicol. 33: 65–73 (1973).

    Article  CAS  Google Scholar 

  • Jaffee, J.H. and Martin, W.R., Narcotic analgesics and antagonists, in: The Pharmacological Basis of Therapeutics, Goodman, L.S. and Gilman, A., eds. Fifth Edition, Macmillan Publ. Co., Inc., New York (1975), pp. 272–276.

    Google Scholar 

  • Jansen, G., Experimentelle Untersuchungen in Form von pharmakologischen Arbeitsversuchen, Med. Exptl. 2: 209–216 (1960).

    CAS  Google Scholar 

  • Krsiak, M., Borgesová, M., and Fernandez, S., Antialcohol effects of some ethanolamine derivatives, Activ. nerv. Super. 13: 198 (1971).

    CAS  Google Scholar 

  • MacLeod, L.D., Monthly Bulletin research report, 1950, Brit. J. Addict. 49: 60–69 (1952).

    Google Scholar 

  • Matchett, J.A. and Erickson, C.K., Alteration of ethanol-induced changes in locomotor activity by adrenergic blockers in mice, Psychopharmacol. 52: 201–206 (1977).

    Article  CAS  Google Scholar 

  • McCrea, F.D. and Taylor, H.M., The use of pentamethylenetetrazol (Metrazol) as a respiratory stimulant in acute alcoholic depression, J. Pharmacol. Exptl. Therap. 68: 41–44 (1940).

    CAS  Google Scholar 

  • Messiha, F.S., Alkali metal ions and ethanol narcosis in mice, Pharmacol. 14: 153–157 (1976).

    Article  CAS  Google Scholar 

  • Messiha, F.S., Modification of the central depressant action of ethanol by amantadine hydrochloride in the mouse, Proc. West. Pharmacol. Soc. 20: 333–337 (1977).

    CAS  PubMed  Google Scholar 

  • Penn, N.W., Ethanol antagonism by 5-hydroxymethyl cellular compounds, Life Sci. 17: 1055–1062 (1975).

    Article  CAS  PubMed  Google Scholar 

  • Redetzki, H.M., The interactions of monoamine oxidase inhibitors (MAOI) with alcohol. Biochemical and pharmacological analysis. Fed. Proc. 26: 616 (1967).

    Google Scholar 

  • Rosenbaum, M., Adaptation of the central nervous system to varying concentrations of alcohol in the blood. Arch. Neurol. Psychiat. 48: 1010–1012 (1942).

    Article  Google Scholar 

  • Rosenfeld, G., Potentiation of the narcotic action and acute toxicity of alcohol by primary aromatic monoamines. Quart. J. Studies Alc. 21: 584–596 (1960).

    CAS  Google Scholar 

  • Rutenfranz, J. and Jansen, G., On compensation of the alcohol effect by caffeine and Pervitin in a psychomotor performance, (Ger.) Intern. Z. Angew. Physiol. 18: 62–81 (1959), (Abstr. Quart. J. Studies Ale. 23: 337, 1962).

    Google Scholar 

  • Sammalisto, L., Effect of glutamine on intoxication by ethyl alcohol. Nature 195: 185 (1962).

    Article  CAS  PubMed  Google Scholar 

  • Siegers, C.-P., Strubelt, O., and Back, G., Inhibition by caffeine of ethanol absorption in rats, Eur. J. Pharmacol. 20: 181–187 (1972).

    Article  CAS  PubMed  Google Scholar 

  • Wallgren, H. and Tirri, R., Studies on the mechanism of stress-induced reduction of alcohol intoxication in rats. Acta Pharmacol. Toxicol. 20: 27–38 (1963).

    Article  CAS  Google Scholar 

  • Wallgren, H. and Barry, H., eds. Actions of Alcohol, Elsevier Publ. Co., Amsterdam, Vol. 2, pp. 622–650 (1970).

    Google Scholar 

  • Ward, C.O., Cam, C.A.L., Tang, A.S.M., Breglia, R.J., and Jarowski, C.I., Effect of lysine on toxicity and depressant effects of ethanol in rats, Toxicol. Appl. Pharmacol. 22: 422–426 (1972).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. College of Pharmacy, The University of Texas, Austin, TX, 78712, USA

    Carlton K. Erickson

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  1. Carlton K. Erickson
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Editors and Affiliations

  1. Downstate Medical Center, Brooklyn, New York, USA

    Henri Begleiter

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© 1980 Plenum Press, New York

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Erickson, C.K. (1980). Requirements for an Ideal Alcohol Antagonist. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_41

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  • DOI: https://doi.org/10.1007/978-1-4684-3632-7_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3634-1

  • Online ISBN: 978-1-4684-3632-7

  • eBook Packages: Springer Book Archive

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