Chronic Ethanol Intake and Synaptosomal Glutamate Binding Activity
The actions of ethanol within the central nervous system (CNS) are undoubtedly multifaceted and ubiquitous. However, a large body of recent neurochemical research strongly suggests that nerve cell membranes may be one of the most significant loci for alcohol’s activity and may provide the key to understanding this agent’s dramatic effects under both acute and chronic intoxication (1,2,3,4,5). Ethanol is capable of interacting with lipid constituents of the membranes as well as with the hydrophobic regions of membrane proteins (1,2), and in this way, may alter the activity of membrane enzymes, ionophores, uptake carriers, and neurotransmitter receptors (3,4,5,6). The interaction between ethanol and any of these membrane-bound proteins could result in changes in neuronal excitability throughout the CNS. It is this potential ethanol-induced alteration in normal excitability characteristics of nerve cell membranes that has been the focus of research efforts in our laboratory.
KeywordsKainic Acid Ethanol Exposure Chronic Ethanol Ethanol Withdrawal Synaptosomal Membrane
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