Ethanol Induced Alterations in Pituitary Gonadal Hormones in Human Males

  • Jack H. Mendelson
  • James Ellingboe
  • Nancy K. Mello
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)


Leydig Cell Alcoholic Liver Disease Plasma Testosterone Ethanol Oxidation Luteinizing Hormone Level 


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  1. Baker, H.W., Berger, H.G., Dekretser, D.M., Dulmanis, A., Hartson, B., O’Connor, S., Paulsen, C.A., Purcell, N., Rennie, G.C., Seah, C.S., Taft, H.P. and Wang, C.: A study of the endocrine manifestations of hepatic cirrhosis. Quart. J. Med. 45:145–178, 1976.PubMedGoogle Scholar
  2. Chin, J.H. and Goldstein, D.B.: Electron paramagnetic resonance studies of ethanol on membrane fluidity. Adv. Exp. Med. Biol. 85A: 111–122, 1977.PubMedCrossRefGoogle Scholar
  3. Cicero, T.J. and Badger, T.M.: A comparative analysis of the effects of narcotics, alcohol and the barbiturates on the hypothalamic-pituitary-gonadal axis. Adv. Exp. Med. Biol. 85B; 95–115, 1977a.PubMedCrossRefGoogle Scholar
  4. Cicero, T.J. and Badger, T.M.: Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the male rat. J. Pharmacol. Exp. Ther. 201: 427–433, 1977b.PubMedGoogle Scholar
  5. Cicero, T.J., Bernstein, D. and Badger, T.M.: Effects of acute alcohol administration on reproductive endocrinology in the male rat. Alcoholism (N.Y.) 2:249–254, 1978.CrossRefGoogle Scholar
  6. Cicero, T.J., Meyer, E.R. and Bell, R.D.: Effects of ethanol on the hypothalamic-pituitary-luteinizing hormone axis and testicular steroidogenesis. J. Pharmacol. Exp. Ther., 1979, (In press).Google Scholar
  7. Earll, J.M., Gaunt, K., Earll, L.A. and Djuh, Y.Y.: Effect of ethyl alcohol on ionic calcium and prolactin in man. Aviat. Space Environ. Med., pp. 808–810, 1976.Google Scholar
  8. Ellingboe, J. and Varanelli, C.C.: Ethanol inhibits testosterone biosynthesis by direct action on Leydig cells. Res. Commun. Chem. Pathol. Pharmacol., 1979 (In press).Google Scholar
  9. Furuyama, S., Mayes, D.M., and Nugent, C.A.: A radioimmunoassay for plasma testosterone. Steroids 16: 415, 1970.PubMedCrossRefGoogle Scholar
  10. Gordon, G.G., Southren, A.L., Altman, K., Rubin, E. and Lieber, C.S.: The effect of alcohol (ethanol) administration on sex hormone metabolism in normal men. New Engl. J. Med. 295; 793–797, 1976.PubMedCrossRefGoogle Scholar
  11. Kent, J.R., Scaramuzzi, R.I. and Lauwers, W.: Plasma testosterone, estradiol and gonadotropins in hepatic insufficiency. Gastroenterology 64: 111–115, 1973.PubMedGoogle Scholar
  12. Lester, R. and Van Thiel, D.D.: Gonadal function in chronic alcoholic men. Adv. Exp. Med. Biol. 85: 399–414, 1977.CrossRefGoogle Scholar
  13. Lloyd, C.W., and William, R.H.: Endocrine changes associated with Laennec’s cirrhosis of the liver. Amer. J. Med. 4: 315–330, 1948.PubMedCrossRefGoogle Scholar
  14. Loosen, P.T. and Prange, A.J., Jr.: Alcohol and anterior-pituitary secretion. Lancet ii: 985, 1977.Google Scholar
  15. Mendelson, J.H., and Mello, N.K.: Alcohol, aggression and androgens. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 52: 225–247, 1974.PubMedGoogle Scholar
  16. Mendelson, J.H., Mello, N.K. and Ellingboe, J.: Effects of acute alcohol intake on pituitary-gonadal hormones in normal human males. J. Pharmacol. Exp. Ther. 202: 676–682, 1977.PubMedGoogle Scholar
  17. Mendelson, J.H., Mello, N.K., and Ellingboe, J.; Effects of alcohol on pituitary-gonadal hormones, sexual function and aggression in human males. In: M.A. Lipton, A. DiMascio and K.F. Killam (Eds.) Psychopharmacology, A Generation of Progress. New York: Raven Press, 1978, pp. 1677–1692.Google Scholar
  18. Rubin, E. Lieber, C.S., Altman, K., Gordon, G.G. and Southren, A.L.: Prolonged ethanol consumption increases testosterone metabolism in the liver. Science 191: 563–564, 1976.PubMedCrossRefGoogle Scholar
  19. Silvestrini, R.: Gynecomastia. Reforma Med. 142: 701, 1926.Google Scholar
  20. Toro, G., Kolodny, R.C., Jacobs, L.S., Master, W.H. and Daughaday, W.H.: Failure of alcohol to alter pituitary and target organ hormone levels. Clin. Res. 21: 505, 1973.Google Scholar
  21. Van Thiel, D.H., Lester, R. and Sherins, R.J.: Hypogonadism in alcoholic liver disease; Evidence for a double defect. Gastroenterology 67: 1188–1199, 1974.PubMedGoogle Scholar
  22. Van Thiel, D.H., Gavaler, J.C., Lester, R. and Goodman, M.D.: Alcohol induced testicular atrophy. An experimental model for hypogonadism occurring in chronic alcoholic men. Gastroenterology 69: 326–332, 1975.PubMedGoogle Scholar
  23. Van Thiel, D.H., McClain, C.J., Elson, M.K. and McMillin, M.J.: Hyperprolactinemia and thyrotropin-releasing factor (TRH) responses in men with alcoholic liver disease. Alcoholism (N.Y.) 2: 344–348, 1978.CrossRefGoogle Scholar
  24. Williams, R.R.: Breast and thyroid cancer and malignant melanoma promoted by alcohol-induced pituitary secretion of prolactin T.S.H., and M.S.H. Lancet i: 996–999, 1976.Google Scholar
  25. Ylikahri, R.H., Huttunen, M.O., Härkönen, O., Leino, T., Helenius, T., Liewendahl, K. and Karonen, S.-L.: Acute effects of alcohol on anterior pituitary secretion of the tropic hormones. J. Clin. Endocrin. & Metab. 46: 715–720, 1978.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Jack H. Mendelson
    • 1
  • James Ellingboe
    • 1
  • Nancy K. Mello
    • 1
  1. 1.Alcohol and Drug Abuse Research Center Harvard Medical SchoolMcLean HospitalBelmontUSA

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