Multiple Effects of Ethanol on the Hypothalamic-Pituitary Gonadal Axis in the Male

  • Theodore J. Cicero
  • Roy D. Bell
  • Thomas M. Badger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)


There are few physiological or biochemical processes which are not influenced in some way by acute or chronic ethanol administration. Among the more prominent affects of the drug are its effects on the endocrine system. In this paper, we would like to review several experiments we have conducted to examine the effects of ethanol on one endocrine system upon which it has particulary profound effects, the hypothalamic-pituitary-gonadal (H-P-G) axis.


Luteinizing Hormone Luteinizing Hormone Release Hormone Luteinizing Hormone Level Ethanol Administration Negative Feedback Control 
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  1. Badr, S. M. and Bartke, A. Effects of alcohol on plasma testosterone levels in mice. Steroids 23:921–927, 1974.PubMedCrossRefGoogle Scholar
  2. Badr, S. M., Bartke, A., Dalterio, S. and Bulger, W. Suppression of testosterone production by ethyl alcohol. Possible mode of action. Steroids 30:647–655, 1977.Google Scholar
  3. Baker, H., Berger, H. G., Dekretser, D. M., Dulmanis, A., Hartson, B., O’Connor, S., Paulsen, C. A., Purcell, N., Rennie, G. C., Seah, C. S., Taft, H. P. and Wang, C. A study of the endocrine manifestations of hepatic cirrhosis. Quart. J. Med. 45: 145–178, 1976.PubMedGoogle Scholar
  4. Cicero, T. J. and Badger, T. M. A comparative analysis of the effects of narcotics, alcohol and the barbiturates on the hypothalamic-pituitary-gonadal axis. Advan. Exp. Med. Biol. 85:95–115, 1977a.CrossRefGoogle Scholar
  5. Cicero, T. J. and Badger, T. M. Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the male rat. J. Pharmacol. Exp. Ther. 201:427–433, 1977b.PubMedGoogle Scholar
  6. Cicero, T. J., Bell, R. D., Meyer, E. R. and Badger, T. M. Ethanol and acetaldehyde directly inhibit testicular steroidogenesis. Mol. Pharmacol., in press (a).Google Scholar
  7. Cicero, T. J., Bernstein, D. and Badger, T. M. Effects of acute alcohol administration on reproductive endocrinology in the male rat. Alc. Clin. Exp. Res. 2:249–254, 1978.CrossRefGoogle Scholar
  8. Cicero, T. J., Meyer, E. R. and Bell, R. D. Effects of ethanol on the hypothalamic-pituitary-luteinizing hormone axis and testicular steroidogenesis. J. Pharmacol. Exp. Ther., in press (b).Google Scholar
  9. Cicero, T. J., Meyer, E. R., Bell, R. D. and Weist, W. Effects of morphine on the secondary sex organs and plasma testosterone level of rats. Res. Commun. Chem. Pathol. Pharmacol. 7:17–24, 1974.Google Scholar
  10. Coppage, W. S. and Cooner, A. E. Testosterone in human plasma. N. Eng. J. Med. 273:902–907, 1965.CrossRefGoogle Scholar
  11. Dalterio, S., Bartke, A. and Burstein, S. Cannabinoids inhibit testosterone secretion by mouse testes in vitro. Science 196:1472–1473, 1977.PubMedCrossRefGoogle Scholar
  12. Dembiec, D., MacNamee, D. and Cohen, G. The effect of pargyline and other monamine oxidase inhibitors on blood acetaldehyde levels in ethanol-intoxicated mice. J. Pharmacol. Exp. Ther. 197:332–339, 1976.PubMedGoogle Scholar
  13. Dufau, M. L., Mendelson, C. R. and Catt, K. J. A highly sensitive in vitro bioassay for luteinizing hormone and chorionic gonadotropin: Testosterone production by dispersed leydig cells. J. Clin. Endocrinol. Metab. 39:610–613, 1974.PubMedCrossRefGoogle Scholar
  14. Galvao-Teles, A., Anderson, D. C., Burke, C. W., Marshall, J. C., Corker, C., Brown, R. C. and Clark, N. L. Biologically active androgens and estradiol in men with chronic liver disease. Lancet 1:173–177, 1973.PubMedCrossRefGoogle Scholar
  15. Gordon, G. G. and Southren, A. L. Metabolic effects of alcohol on the endocrine system. In C. S. Lieber (Ed.) Metabolic Aspects of Alcoholism, pp. 249–272. Baltimore, University Park Press, 1977.CrossRefGoogle Scholar
  16. Gordon, G. G., Southren, A. L., Altman, K., Rubin, E. and Lieber, C. S. The effect of alcohol (ethanol) administration on sex hormone metabolism in normal men. N. Engl. J. Med. 295:793- 797, 1976.Google Scholar
  17. Gordon, G. G., Southren, A. L. and Lieber, C. S. The effects of alcoholic liver disease and alcohol ingestion on sex hormone levels. Alc. Clin. Exp. Res. 2:259–264, 1978.CrossRefGoogle Scholar
  18. Kent, J. R., Scaramuzzi, R. I. and Lauwers, W. Plasma Testosterone, estradiol and gonadotropins in hepatic insufficiency. Gastroenterology 64:111–115, 1973.PubMedGoogle Scholar
  19. Korsten, M. A., Matsuzaki, S., Feinman, L. and Lieber, C. S. High blood acetaldehyde levels after ethanol administration. Difference between alcoholic and nonalcoholic subjects. N. Engl. J. Med. 292:386–389, 1975.PubMedCrossRefGoogle Scholar
  20. Leppäluoto, J., Rapeli, M., Voris, R. and Ranta, T. Secretion of anterior pituitary hormones in man: Effect of ethyl alcohol. Acta Physiol. Scand. 95:400–406, 1975.PubMedCrossRefGoogle Scholar
  21. Lester, R. and VanThiel, D. H. Gonadal function in chronic alcoholic men. Advan. Exp. Med. Biol. 85A:399–414, 1977.CrossRefGoogle Scholar
  22. Mendelson, J. H., Ellingboe, J., Mello, N. K. and Kuehnle, J. Effects of alcohol on plasma testosterone and luteinizing hormone levels. Ale. Clin. Exp. Res. 2:255–258, 1978a.CrossRefGoogle Scholar
  23. Mendelson, J. H., Mello, N. K. and Ellingboe, J. Effects of acute alcohol intake on the pituitary-gonadal hormone in normal human males. J. Pharmacol. Exp. Ther. 202:676–682, 1977.PubMedGoogle Scholar
  24. Mendelson, J. H., Mello, N. K. and Ellingboe, J. Effects of Alcohol on Pituitary-Gonadal Hormones, Sexual Function, and Agression in Human Males. In M. A. Lipton, A. DiMascio and K. F. Killam (Eds.) Psychopharmacology; A Generation of Progress, pp. 1677–1692. New York, Raven Press, 1978b.Google Scholar
  25. Moyle, W. R. and Ramachandran, J. Effect of LH on steroidogenesis and cyclic-AMP accumulation in rat Leydig cell preparations and mouse tumor Leydig cells. Endocrinology 93:127–134, 1973.PubMedCrossRefGoogle Scholar
  26. Niswender, G. O., Reichert, L. E., Midgley, A. R. and Nalbandov, A. V. Radioimmunoassay for bovine and ovine luteinizing hormone. Endocrinology 84:1166–1173, 1969.PubMedCrossRefGoogle Scholar
  27. Petersen, D. R., Collins, A. C. and Deitrich, R. A. Role of liver cytosolic aldehyde dehydrogenase isozymes in control of blood acetaldehyde concentrations. J. Pharmacol. Exp. Ther. 201:471–481, 1977.PubMedGoogle Scholar
  28. Rowe, P. H., Racey, P. A., Shenton, J. C., Ellwood, M. and Lehane, J. Effects of acute administration of alcohol and barbiturates on plasma luteinizing hormone and testosterone in man. J. Endocrinol. 63:50P, 1974.CrossRefGoogle Scholar
  29. Rubin, E., Lieber, C. S., Altman, K., Gordon, G. G. and Southren, A. L. Prolonged ethanol consumption increases testosterone metabolism in the liver. Science (Washington) 91:563–564, 1976.CrossRefGoogle Scholar
  30. Smith, E. R. and Davidson, M. J. Location of feedback receptors; Effects of intracranially implanted steroids on plasma LH and LRF response. Endocrinology 95:1566–1573, 1974.PubMedCrossRefGoogle Scholar
  31. Southren, A. L., Gordon, G. G., Olivo, J., Rafii, F. and Rosenthal, W. S. Androgen metabolism in cirrhosis of the liver. Metabolism 22:695–702, 1973.PubMedCrossRefGoogle Scholar
  32. Symons, A. M. and Marks, V. Effects of alcohol on weight gain and the hypothalamic-pituitary-gonadotropin axis in the maturing male rat. Biochem. Pharmacol. 24:955–958, 1975.PubMedCrossRefGoogle Scholar
  33. Toro, G., Kolodney, R. C., Jacobs, L. S., Masters, W. H. and Daughaday, W. H. Failure of alcohol to alter pituitary and target hormone levels. Clin. Res. 21:505, 1973.Google Scholar
  34. Truitt, E. B. and Walsh, M. J. The role of acetaldehyde in the actions of alcohol. In B. Kissin and H. Begleiter (Eds.) The Biology of Alcoholism, vol. 1, pp. 161–195. New York Plenum Press, 1971.CrossRefGoogle Scholar
  35. VanThiel, D. H., Gavaler, J. and Lester, R. Ethanol inhibition of Vitamin A Metabolism in the testes: Possible mechanism for sterility in alcoholics. Science 186:941–942, 1974.PubMedCrossRefGoogle Scholar
  36. VanThiel, D. H., Gavaler, J. S., Lester, R. and Goodman, M. D. Alcohol induced testicular atrophy: An experimental model for hypogonadism occurring in chronic alcoholic men. Gastroenterology 69:326–332, 1975a.PubMedGoogle Scholar
  37. VanThiel, D. H., Gavaler, J. S., Lester, R., Loriaus, D. L. and Brownstein, G. D. Plasma estrone, prolactin, neurophysin and sex steroid-binding globulin in chronic alcoholic men. Metabolism 24:1015–1019, 1975b.PubMedCrossRefGoogle Scholar
  38. VanThiel, D. H. and Lester, R. Further evidence for hypothalamicpituitary dysfunction in alcoholic men. Alc. Clin. Exp. Res. 2:265–770, 1978.CrossRefGoogle Scholar
  39. VanThiel, D. H., Lester, R. and Sherins, R. J. Hypogonadism in alcoholic liver disease: Evidence for a double defect. Gastroenterology 67:1188–1199, 1974.PubMedGoogle Scholar
  40. Ylikahri, R., Huttunen, M., Harkonen, M., Seuderling, U., Onikki, S., Kardnen, S. L. and Adlercreutz, H. Low plasma testosterone values in men during hangover. J. Steroid Biochem. 5:655–658, 1974.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Theodore J. Cicero
    • 1
  • Roy D. Bell
    • 1
  • Thomas M. Badger
    • 2
  1. 1.Department of PsychiatryWashington University School of MedicineSt. LouisUSA
  2. 2.Vincent Research LaboratoryMassachusetts General HospitalBostonUSA

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