Acetaldehyde Levels in Peripheral Venous Blood and Breath of Human Volunteers
If the extrahepatic metabolism of acetaldehyde in humans is similar to that which occurs in rats (1-6), venous blood acetaldehyde concentrations may not reflect those in potentially sensitive organs such as the brain. It is important to obtain estimates of the levels of acetaldehyde in blood (a) leaving the liver, in order to determine the maximum toxic potential of acetaldehyde, and (b) presented to the brain, since current theories proposing a role for acetaldehyde in the development of addiction to ethanol involve its interaction with components of the central nervous system (7,8).
KeywordsPeripheral Venous Blood Partition Ratio Acetaldehyde Level Blood Ethanol Concentration Hepatic Venous Blood
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