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Hepatotoxicity of Acetaldehyde

  • C. S. Lieber
  • E. Baraona
  • Y. Matsuda
  • M. Salaspuro
  • Y. Hasumura
  • S. Matsuzaki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)

Abstract

All known pathways of ethanol oxidation in the liver result in production of acetaldehyde. Until recently, however, the fate of this metabolite of ethanol has been rather neglected because of methodological difficulties in its measurement. However, recent technological advancements have permitted the development of acceptable methods to detect acetaldehyde in biological fluids. A number of studies have been initiated which already have documented profound involvement of acetaldehyde in the metabolic and toxic effects of ethanol. This is not an unexpected development, in view of the known chemical reactivity of this metabolite. In this paper, we shall particularly focus on some alterations after chronic ethanol consumption particularly in the liver.

Keywords

Aldehyde Dehydrogenase Chronic Ethanol Ethanol Oxidation Acetaldehyde Concentration Ethanol Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • C. S. Lieber
    • 1
  • E. Baraona
    • 1
  • Y. Matsuda
    • 1
  • M. Salaspuro
    • 1
  • Y. Hasumura
    • 1
  • S. Matsuzaki
    • 1
  1. 1.Alcoholism Research and Treatment CenterBronx Veterans Hospital and Mt. Sinai School of Medicine of the City University of New YorkN.Y.USA

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