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Influence of Prolonged Ethanol Intake on the Levels and Turnover of Alcohol and Aldehyde Dehydrogenases and Glutathione

  • Consuelo Guerri
  • Santiago Grisolia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)

Abstract

In spite of much work, especially recently, much remains to be known regarding molecular aspects of acute and particularly of chronic ethanol toxicity (1,2). Much less is known, except in extreme cases, regarding methanol toxicity. Nevertheless, it is believed that acute toxicity (other than the innebriating effects similar to those resulting from ethanol which are largely due to unclarified neural mechanisms) results from acidotic effects arising from aldehyde fromation and its oxidation to formic acid. In regard to non-lethal but equally acute detrimental effects on the eye, it has been shown (3) that formaldehyde interfers with the generation of ATP during oxidative phosphorylation, which results in loss of vision.

Keywords

Alcohol Dehydrogenase Aldehyde Dehydrogenase Ethanol Consumption Ethanol Intake Ethanol Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Consuelo Guerri
    • 1
    • 2
  • Santiago Grisolia
    • 1
    • 2
  1. 1.Instituto de Investigaciones CitologicasValenciaSpain
  2. 2.Dept. Biochem.U. Kansas Med. Ctr.Kansas City, KansasUSA

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