Abstract
Tertiary alcohols, for all practical purposes, are not oxidatively metabolized. Thus, t-butanol is a potentially useful tool to evaluate whether a given biologic action is due to alcohol or one of its metabolic products. Previously, several groups have shown that t-butanol can produce physical dependence in the rat (Wallgren et al., 1973; Thurman and Pathman, 1975) at doses which are 4- to 5-fold lower than ethanol. Also, t-butanol is 4 to 5 times more lipid soluble than ethanol, indicating that the dose of an alcohol necessary to produce physical dependence is inversely related to its lipid solubility.
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© 1980 Plenum Press, New York
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Thurman, R.G., Winn, K., Urquhart, B. (1980). Rat Brain Cyclic Amp Levels and Withdrawal Behavior following Treatment with t-Butanol. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_22
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DOI: https://doi.org/10.1007/978-1-4684-3632-7_22
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