Rat Brain Cyclic Amp Levels and Withdrawal Behavior following Treatment with t-Butanol
Tertiary alcohols, for all practical purposes, are not oxidatively metabolized. Thus, t-butanol is a potentially useful tool to evaluate whether a given biologic action is due to alcohol or one of its metabolic products. Previously, several groups have shown that t-butanol can produce physical dependence in the rat (Wallgren et al., 1973; Thurman and Pathman, 1975) at doses which are 4- to 5-fold lower than ethanol. Also, t-butanol is 4 to 5 times more lipid soluble than ethanol, indicating that the dose of an alcohol necessary to produce physical dependence is inversely related to its lipid solubility.
KeywordsPhysical Dependence Pyridine Nucleotide Alcohol Withdrawal Syndrome Tertiary Alcohol Withdrawal Behavior
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