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Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates

  • J. M. Khanna
  • A. D. Le
  • H. Kalant
  • A. E. LeBlanc
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)

Abstract

Previously it has been shown that chronic administration of p-chlorophenylalanine (p-CPA), slowed the development of tolerance to ethanol, pentobarbital and cross-tolerance development to ethanol in rats chronically treated with pentobarbital. These findings have been extended by the following observations:
  1. (1)

    p-CPA slowed the development of tolerance to barbital as measured by motor impairment on the moving belt test, without altering the acute response.

     
  2. (2)

    p-CPA also reduced the tolerance to barbital as measured by sleeping time, in animals chronically treated with pentobarbital.

     
  3. (3)

    Administration of L-tryptophan increased the rate of tolerance development to ethanol as measured by motor impairment and hypothermia.

     

These results further confirm and extend the generality of our observations that 5-HT may be involved in the development of tolerance and cross-tolerance to sedatives.

Keywords

Chronic Treatment Motor Impairment Test Dose Chronic Ethanol Morphine Tolerance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. M. Khanna
    • 1
  • A. D. Le
    • 1
  • H. Kalant
    • 1
  • A. E. LeBlanc
    • 1
  1. 1.Department of PharmacologyUniversity of Toronto and Addiction Research Foundation of OntarioTorontoCanada

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