Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates
p-CPA slowed the development of tolerance to barbital as measured by motor impairment on the moving belt test, without altering the acute response.
p-CPA also reduced the tolerance to barbital as measured by sleeping time, in animals chronically treated with pentobarbital.
Administration of L-tryptophan increased the rate of tolerance development to ethanol as measured by motor impairment and hypothermia.
These results further confirm and extend the generality of our observations that 5-HT may be involved in the development of tolerance and cross-tolerance to sedatives.
KeywordsChronic Treatment Motor Impairment Test Dose Chronic Ethanol Morphine Tolerance
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