Acute and Chronic Effects of Barbiturates on Regional Turnover of Acetylcholine in Brain

  • Agneta Nordberg
  • Göran Wahlström
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)


Data concerning both the acute and chronic effects of barbiturates on acetylcholine [ACh] turnover in mouse and rat brain are presented

A single anaesthetic dose of pentobarbital [60 mg/kg, i.p.] to mice increased the endogenous content of ACh and decreased the turnover of ACh in the hippocampus and cortex. No effect was found in the striatum

At sacrifice after chronic treatment with barbital to rats for about 30 weeks no effect was found on the endogenous ACh content. 3 days after the barbital solution was replaced by water [at the day with maximal number of abstinence convulsions] the amount of endogenous ACh was decreased by 35% in the striatum in comparison with control and the decrease was still significant after 30 days of abstinence

The biosynthesis of radioactive ACh from a tracer dose of radioactive choline [Ch] was increased in the cerebellum+midbrain+medulla oblongata of rats receiving barbital until sacrifice and rats abstinent for 3 days. It was also increased in the hippocampus+cortex on the 3rd abstinent day. No significant effect on the ACh formation was found in the striatum


Microwave Irradiation Medulla Oblongata speciFic Radioactivity Tracer Dose Acta Physiol 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Agneta Nordberg
    • 1
    • 2
  • Göran Wahlström
    • 1
    • 2
  1. 1.Dept. of PharmacologyUniv. of Uppsala23 UppsalaSweden
  2. 2.Dept. of PharmacologyUniversity of Umeå87 UmeåSweden

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