Cyclic Amp And ß-Adrenergic Receptors during The Development Of Physical Dependence On Ethanol In The Rat
Although the percentage of noradrenergic neurons in the central nervous system is small, several lines of investigation suggest that they may be in some way involved in mechanisms responsible for tolerance and physical dependence on ethanol. For example, Goldstein (1973) has demonstrated that excitability during the withdrawal reaction following termination of treatment with ethanol is more intense if norepinephrine is depleted pharmacologically. In addition, the intensity of the withdrawal reaction in three different strains of mice correlated well with intensity of convulsions induced by reserpine, an agent known to deplete cellular stores of norepinephrine, Furthermore, French et al. (1975) have reported that the cerebral cortical adenylate cyclase becomes subsensitive to norepinephrine during treatment with ethanol whereas it becomes supersensitive several days after ethanol is withdrawn. On the other hand, Tabakoff and Ritzmann (1977) failed to detect any effect of destruction of noradrenergic neurons with 6-hydroxydopamine on the withdrawal reaction due to ethanol.
KeywordsAdenylate Cyclase Physical Dependence Ethanol Treatment Noradrenergic Neuron Protein Binding Assay
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