Examination of the Role of Tetrahydroisoquinoline Alkaloids in The Mediation of Ethanol Consumption in Rats

  • Z. W. Brown
  • Z. Amit
  • B. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 126)


Although the central mechanisms mediating the voluntary consumption of ethanol have not as yet been determined, a number of hypotheses have been proposed based on the available evidence. The biogenic amines that have been implicated in the mediation of reward (e.g. Fibiger, 1978; German and Bowden, 1974; Stein 1968; Zigmond and Strieker, 1972) have also been shown to play a functional role in the pharmacological actions of ethanol. This notion has been supported by the numerous demonstrations that ethanol administration produces alterations in the metabolism of the central biogenic amines (e.g. Bonnycastle, Bonnycastle and Anderson, 1962; Carlsson, Magnusson, Svensson and Waldeck, 1973; Corrodi, Fuxe and Hokfelt, 1966; Hunt and Majchrowicz, 1974). While the effects of serotonin (5-HT) manipulations on ethanol consumption have been equivocal (e.g. Hill, 1974; Myers, 1968; Myers and Melchior, 1975a, b), there has been greater consistency in the reports that catecholamines (CA), and norepinephrine (NE) in particular, may mediate the reinforcing properties of ethanol(e.g. Amit, Brown, Levitan and Ogren, 1977; Amit and Stern, 1971; Brown and Amit, 1977; Davis, Smith and Werner, 1977; Myers and Melchior, 1975a).


Biogenic Amine Ethanol Consumption Ethanol Intake Cannula Guide Ethanol Administration 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Z. W. Brown
    • 1
  • Z. Amit
    • 1
  • B. Smith
    • 1
  1. 1.Center for Research on Drug Dependence, Department of PsychologyConcordia UniversityMontrealCanada

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