Halogenated Biphenyl Metabolism
The metabolism of xenobiotics occurs predominantly in the liver and is generally effected in two related phases. Phase I biotransformation includes oxidation, reduction and hydrolysis which either introduces or exposes a more polar substituent or group such as -OH, -SH, -NH2 and -COOH, Phase II biotransformation includes addition reactions which conjugate the electronegative group introduced or exposed during phase I metabolism with endogenous acids. A feature characteristic of these diverse biotransformations is that the metabolic products are generally more hydrophilic than the parent compound and this expedites their renal and biliary excretion.
KeywordsMicrosomal Enzyme Aryl Hydrocarbon Hydroxylase Electronegative Group Polar Substituent Ambystoma Tigrinum
Unable to display preview. Download preview PDF.
- Billings, R.E., and R.E. McMahon: Mol. Pharmacol. 14 (1978) 145.Google Scholar
- Crawford, A., and S. Safe: Res. Comm. Chem. Pathol. Pharmacol. 18 (1977) 59.Google Scholar
- Creaven, P.J., and D.V. Parke: Biochem. Pharmacol. 7 (1966) 16.Google Scholar
- Felton, J.S., and D.W. Nebert: J. Biol. Chem. 250 (1975) 6769.Google Scholar
- Felton, J.S., D.W. Nebert, and S.S. Thorgeirsson: Mol. Pharmacol. 12. (1976) 225.Google Scholar
- Gillette, J.R.: Isr. J. Chem. 14 (1975) 193.Google Scholar
- McPherson, F.J., J.W. Bridges, and D.V. Parke: Biochem. J. 154 (1976) 773.Google Scholar
- Nebert, D.W., R.C. Levitt, M.M. Orlando, and J.S. Felton: Clin. Pharmacol. Therap. 22 (1977) 640.Google Scholar
- Weinstein, I.B.: Bull. N.Y. Acad. Med. 54 (1978) 366.Google Scholar
- Wyndham, C., J. Devenish, and S. Safe: Res. Comm. Chem. Pahtol. Pharmacol. 15 (1976) 563.Google Scholar
- Wyndham, C. and S. Safe: Can. J. Biochem. In press. (1978).Google Scholar