Induction of Mixed Function Oxidase Enzymes in Fish by Halogenated and Aromatic Hydrocarbons
Several representative halogenated and aromatic hydrocarbon environmental contaminants were fed to trout and their effects on hepatic mixed function oxidase (MFO) enzyme systems studied. The insecticide p,p’-DDT and its metabolite p,p’-DDE did not induce the trout MFO enzyme system whereas the polycyclic aromatic 3-methyl-cholanthrene and the polychlorinated biphenyl Aroclor 1254 induced various components of this system, most dramatically ethoxycoumarin O-de-ethylase activity. A PCB replacement composed of chlorinated butylated diphenyl ethers (XFS-4169 L: Dow Chemical Co.) had no effect on trout MFO activity other than a slight increase in cytochrome P-450 concentration.
KeywordsControl Fish Microsomal Protein Mixed Function Oxidase Aniline Hydroxylase Mixed Function Oxidase System
Unable to display preview. Download preview PDF.
- Addison, R.F., M.E. Zinck, and D.E. Willis. 1977. Comp. Biochem. Physiol. 57C: 39–43.Google Scholar
- Addison, R.F., M.E. Zinck, and D.E. Willis. 1978a. Comp. Biochem. Physiol. In Press.Google Scholar
- Addison, R.F., M.E. Zinck, D.E. Willis, and D.C. Darrow. 1978b (Unpublished results).Google Scholar
- Willis, D.E., M.E. Zinck, and R.F. Addison. 1978, Chemosphere. Submitted.Google Scholar