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Induction of Mixed Function Oxidase Enzymes in Fish by Halogenated and Aromatic Hydrocarbons

  • D. E. Willis
  • M. E. Zinck
  • D. C. Darrow
  • R. F. Addison
Part of the Environmental Science Research book series (ESRH, volume 16)

Abstract

Several representative halogenated and aromatic hydrocarbon environmental contaminants were fed to trout and their effects on hepatic mixed function oxidase (MFO) enzyme systems studied. The insecticide p,p’-DDT and its metabolite p,p’-DDE did not induce the trout MFO enzyme system whereas the polycyclic aromatic 3-methyl-cholanthrene and the polychlorinated biphenyl Aroclor 1254 induced various components of this system, most dramatically ethoxycoumarin O-de-ethylase activity. A PCB replacement composed of chlorinated butylated diphenyl ethers (XFS-4169 L: Dow Chemical Co.) had no effect on trout MFO activity other than a slight increase in cytochrome P-450 concentration.

Keywords

Control Fish Microsomal Protein Mixed Function Oxidase Aniline Hydroxylase Mixed Function Oxidase System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • D. E. Willis
    • 1
  • M. E. Zinck
    • 1
  • D. C. Darrow
    • 1
  • R. F. Addison
    • 1
  1. 1.Fisheries and Marine Service, Marine Ecology LaboratoryBedford Institute of OceanographyDartmouthUSA

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