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Are Differences in the Disulfiram-Alcohol Reaction the Basis of Racial Differences in Biological Sensitivity to Ethanol?

  • Arthur R. Zeiner

Abstract

Ingestion of alcohol is a prerequisite for becoming an alcoholic. However, neither do all people drink alcohol equally nor are they all equally at risk for becoming alcoholics. There are large individual differences in both alcohol use and abuse. Such data leave the researcher with perplexing questions. Why is it that some people choose not to drink (for other than financial or religious reasons), why are some others indifferent to alcohol and why do some people prefer to drink alcohol? What factors govern the self-selection of alcoholic beverages? In partial answer to some of these questions, it has been proposed that there exist differences in biological sensitivity to alcohol which may modulate the self-selection process (Kalow, 1962; Wolff, 1972). Implicit in the biological sensitivity hypothesis is the notion that some people experience predominantly pleasant effects from alcohol ingestion whereas others experience mainly unpleasant effects. Further, it is assumed that the experience of pleasant-unpleasant effects has a biological basis.

Keywords

Heart Rate Increase Ethanol Ingestion Blood Alcohol Concentration Acetaldehyde Concentration Acute Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Akabane, J. 1970. Aldehydes and related compounds. In: J. Tremo-lieres (Ed.), 7 of Pharmacology and Therapeutics. Oxford: Permagon Press, Volume II, Section 20, pages 523–560.Google Scholar
  2. Asmussen, E., Hald, J., Jacobsen, E. and Jorgensen, G. 1948. Studies on the effect of tetraethylthiuram disulphide ( Antabuse) and alcohol on respiration and circulation in normal human subjects. 7. 4, 297–304.CrossRefGoogle Scholar
  3. Asmussen, E., Hald, J., and Larsen, V. 1948. The pharmacological action of acetaldehyde on the human organism. Acta Pharmacologica. 4, 311–320.CrossRefGoogle Scholar
  4. Eade, N.R. 1959. Mechanism of sympathomimetic action of aldehydes. J. Pharmacol. and Exp. Ther. 127, 29–34.Google Scholar
  5. Ewing, J.A., Rouse, B.A. and Pellizzari, E.D. 1974. Alcohol sensitivity and ethnic background. American Journal of Psychiatry. 131, 206–210.Google Scholar
  6. Farris, J.J. and Jones, B.M. 1978. Ethanol metabolism in male American Indians and Whites. Alcoholism: Clinical and Experimental Research. 2, 77–81.CrossRefGoogle Scholar
  7. Gillespie, J.A. 1976. Vasodilator properties of alcohol. British Medical Journal. 2, 274–277.CrossRefGoogle Scholar
  8. Hald, J., and Jacobsen, E. 1948. The formation of acetaldehyde on the organism after ingestion of Antabuse (Tetraethylthiuram disulphide) and alcohol. Acta. Pharmacol. 4, 305–310.CrossRefGoogle Scholar
  9. Hald, J., Jacobsen, E. and Larsen, V. 1948. The sensitizing effect of tetraethylthiuram disulphide ( Antabuse) to ethyl alcohol. Acta Pharmacologica Toxicol. 4, 285–296.CrossRefGoogle Scholar
  10. Hanna, J. 1977. Cardiovascular response of Chinese, Japanese and Caucasians to alcohol. Paper presented at the NATO International Conference on Behavioral Approaches to Alcoholism, Bergen, Norway, August, 1977.Google Scholar
  11. Ijiri, J. 1974. Studies on the relationship between concentrations of blood acetaldehyde and urinary catecholamine and the symptoms after drinking alcohol. Japanese Journal of Studies on Alcohol. 3, 35–39.Google Scholar
  12. Kalow, W. 1962. Pharmacogenetics, Heredity and the Response to Drugs. Philadelphia: B.W. Saunders.Google Scholar
  13. Morikawa, Y., Matsuzaka, J., Kuratsune, M., Tsukamoto, S. and Mikisumi, S. 1968. Plethysmographic study of effects of alcohol. Nature. 220, 186–187.CrossRefGoogle Scholar
  14. Naitoh, P. 1972. The effect of alcohol on the autonomic nervous system of humans: psychophysiological approach. In: B. Kissin and H. Begleiter (Eds.), The Biology of Alcoholism. New York: Plenum Press.Google Scholar
  15. Raby, K. 1953a. Investigations of the Disulfiram-Alcohol reaction. Quarterly Journal of Studies on Alcohol. 14, 545–556.Google Scholar
  16. Raby, K. 1953b. Electrocardiographic changes following the ingestion of disulfiram and alcohol. Quarterly Journal of Studies on Alcohol. 14, 557–567.Google Scholar
  17. Zeiner, A.R., Paredes, A. and Cowden, L. 1976. Physiological responses to ethanol among Tarahumara Indians. Annals of the New York Academy of Sciences. 273, 151–158.CrossRefGoogle Scholar
  18. Zeiner, A.R., Paredes, A., Musicant, R. and Cowden, L. 1977. Racial differences in psychophysiological responses to ethanol and placebo. In: F.A. Seixas (Ed.), Currents in Alcoholism, Vol. I, New York: Crune and Stratton, 271–286.Google Scholar
  19. Zeiner, A.R., Paredes, A. and Christensen, H.D. 1977. Relationships between acetaldehyde blood alcohol concentrations and physiolog-ical reactivity to an acute dose of ethanol among different racial groups. Paper presented at the NATO International Conference on Behavioral Approaches to Alcoholism, Bergen, Norway, August.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Arthur R. Zeiner
    • 1
  1. 1.The University of Oklahoma Health Sciences CenterUSA

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