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Antagonism of Cocaine Highs by Lithium

  • Alvin J. Cronson
  • Abraham Flemenbaum

Abstract

According to Jefferson and Greist (1977), the interest on the beneficial effects of lithium for amphetamine abuse was aroused by a report by Flemenbaum (1974) on two patients who spontaneously stopped abusing amphetamines because they no longer experienced the expected high while taking lithium. A third patient receiving lithium for weight reduction did not experience appetite suppression or highs of the subjective effects until lithium was discontinued. Flemenbaum’s concept was further supported by a placebo-control double blind study of nine severely depressed patients in whom lithium treatment resulted in a 60% reduction in the activation and euphoria responses to d-amphetamine and almost complete abolition of response to l-amphetamine (Van Kamen and Murphy, 1975).

Keywords

Subjective Effect Complete Abolition Dose Lithium Married Male Lithium Administration 
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References

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Alvin J. Cronson
    • 1
  • Abraham Flemenbaum
    • 1
  1. 1.Texas Tech University School of MedicineUSA

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