Antagonism of Cocaine Highs by Lithium

  • Alvin J. Cronson
  • Abraham Flemenbaum


According to Jefferson and Greist (1977), the interest on the beneficial effects of lithium for amphetamine abuse was aroused by a report by Flemenbaum (1974) on two patients who spontaneously stopped abusing amphetamines because they no longer experienced the expected high while taking lithium. A third patient receiving lithium for weight reduction did not experience appetite suppression or highs of the subjective effects until lithium was discontinued. Flemenbaum’s concept was further supported by a placebo-control double blind study of nine severely depressed patients in whom lithium treatment resulted in a 60% reduction in the activation and euphoria responses to d-amphetamine and almost complete abolition of response to l-amphetamine (Van Kamen and Murphy, 1975).


Subjective Effect Complete Abolition Dose Lithium Married Male Lithium Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cox, C., Harrison-Read, P.E., Steinberg, H., et al. 1971. Lithium attenuates drug-induced hyperactivity in rats. Nature. 232: 336–338.CrossRefGoogle Scholar
  2. Flemenbaum, A. 1974. Dose lithium block the effects of amphetamine? A report of three cases. Am. J. Psychiatry. 131: 820–821.Google Scholar
  3. Flemenbaum, A. 1977. Antagonism of behavioral effects of cocaine by lithium. Pharmacol. Biochem. Behay. 7: 83–85.CrossRefGoogle Scholar
  4. Furukawa, T., Ushizima, I, and Ono, N. 1975. Modifications by lithium of behavioral responses to methamphetamine and tetrabenazine. Psychopharmacologia (Berl.) 42: 243–248.CrossRefGoogle Scholar
  5. Jefferson, J.W. and Greist, J.H. 1977. Primer of Lithium Therapy. Baltimore: Williams and Wilkins Co.Google Scholar
  6. Lal, S. and Sourkes, T.L. 1972. Potentiation and inhibition of the amphetamine sterotypy in rats by neuroleptics and other agents. Arch. Int. Pharmacodyn. Ther. 199: 289–301.Google Scholar
  7. Poitou, P., Boulu, R., and Bohuon, C. 1975. Effect of lithium and other drugs on the amphetamine chlordizaepoxide hyperactivity in mice. Experientia. 31: 99–101.CrossRefGoogle Scholar
  8. Van Kammen, D.P. and Murphy, D.L. 1975. Attenuation of the euphoriant and activating effects of d-and 1-amphetamine by lithium carbonate treatment. Psychopharmacologia. 44: 215–224.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Alvin J. Cronson
    • 1
  • Abraham Flemenbaum
    • 1
  1. 1.Texas Tech University School of MedicineUSA

Personalised recommendations