Antagonism of Cocaine Highs by Lithium
According to Jefferson and Greist (1977), the interest on the beneficial effects of lithium for amphetamine abuse was aroused by a report by Flemenbaum (1974) on two patients who spontaneously stopped abusing amphetamines because they no longer experienced the expected high while taking lithium. A third patient receiving lithium for weight reduction did not experience appetite suppression or highs of the subjective effects until lithium was discontinued. Flemenbaum’s concept was further supported by a placebo-control double blind study of nine severely depressed patients in whom lithium treatment resulted in a 60% reduction in the activation and euphoria responses to d-amphetamine and almost complete abolition of response to l-amphetamine (Van Kamen and Murphy, 1975).
KeywordsSubjective Effect Complete Abolition Dose Lithium Married Male Lithium Administration
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- Flemenbaum, A. 1974. Dose lithium block the effects of amphetamine? A report of three cases. Am. J. Psychiatry. 131: 820–821.Google Scholar
- Jefferson, J.W. and Greist, J.H. 1977. Primer of Lithium Therapy. Baltimore: Williams and Wilkins Co.Google Scholar
- Lal, S. and Sourkes, T.L. 1972. Potentiation and inhibition of the amphetamine sterotypy in rats by neuroleptics and other agents. Arch. Int. Pharmacodyn. Ther. 199: 289–301.Google Scholar