Phase III LAAM Study: An Interim Report
Levo-alpha-acetylmethadol (LAAM) is a derivative of methadone not inappropriately referred to by patients as “long-acting methadone.” While LAAM was originally developed during World War II as an analgesic, it was found to be inappropriate for that purpose due to the slow-acting onset of its psychoactivity. Further testing of the drug was delayed until the early 1950’s when Isbell and Fraser (Fraser and Isbell, 1952; Fraser, Nash, Vanhorn, and Isbell, 1954) demonstrated the drug’s opiate-like profile. LAAM was found by them to be equally as efficacious as methadone in preventing the occurrence of withdrawal symptoms in morphine dependent subjects. Furthermore, since LAAM has an extremely long duration of action which can persist over 72 hours after a single oral dose it can be clearly advantageous for use in drug-dependent individuals.
KeywordsMethadone Maintenance Interim Report Methadone Maintenance Therapy Heroin Addict Heroin Dependence
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