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Naloxone “Flush”: A Novel Approach to Complete Heroin Abstinence

  • Alvin J. Cronson

Abstract

Naloxone hydrochloride is a specific narcotic antagonist whose main use is the reversal of coma due to opiates. In 1973 the Drug Research Unit of New York Medical College used it to test the patients’ freedom from opiates, prior to the administration of naltrexone, which is more potent and has a longer duration. Both patients and staff called this procedure a “flush.” If naloxone was administered too soon, generally less than a week after termination of methadone maintenace, abstinence symptoms such as muscle cramps, nausea and hypersecretions would occur. These could be symptomatically treated with diazapam, prochlorpromazine and atropine.

Keywords

Muscle Cramp York Medical College Abstinence Syndrome Opiate Dependence 34th Annual Scientific 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Alvin J. Cronson
    • 1
  1. 1.Texas Tech University School of MedicineUSA

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