A Summary of the Phase II Clinical Studies of the Narcotic Antagonist, Naltrexone
In an effort to develop a pharmacologic alternative to methadone in the treatment of opiate dependent individuals, the Special Action Office for Drug Abuse Prevention (SAODAP) contracted, in June of 1973, with the Division of Medical Sciences at the National Academy of Sciences National Research Council (NAS/NRC) to select one of several narcotic antagonists for use in a NAS-administered research study. Among the various narcotic antagonists available at the time were cyclazocine, naloxone, and naltrexone. The Committee on Clinical Evaluation of Narcotic Antagonists (CENA), formed by the NAS/NRC, selected naltrexone as the “best” among the various contenders because of its effectiveness as an antagonist, its extended span of action, its expected margin of safety, and its relative lack of agonist activity (Renault, 1976).
KeywordsIdiopathic Thrombocytopenic Purpura Methadone Maintenance Narcotic Antagonist Placebo Subject Methadone Maintenance Program
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