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A Summary of the Phase II Clinical Studies of the Narcotic Antagonist, Naltrexone

  • H. Alex Bradford
  • Samuel C. Kaim
  • Walter Ling

Abstract

In an effort to develop a pharmacologic alternative to methadone in the treatment of opiate dependent individuals, the Special Action Office for Drug Abuse Prevention (SAODAP) contracted, in June of 1973, with the Division of Medical Sciences at the National Academy of Sciences National Research Council (NAS/NRC) to select one of several narcotic antagonists for use in a NAS-administered research study. Among the various narcotic antagonists available at the time were cyclazocine, naloxone, and naltrexone. The Committee on Clinical Evaluation of Narcotic Antagonists (CENA), formed by the NAS/NRC, selected naltrexone as the “best” among the various contenders because of its effectiveness as an antagonist, its extended span of action, its expected margin of safety, and its relative lack of agonist activity (Renault, 1976).

Keywords

Idiopathic Thrombocytopenic Purpura Methadone Maintenance Narcotic Antagonist Placebo Subject Methadone Maintenance Program 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bradford, A. and Kaim, S. 1977. Final Report: Double-Blind Place-bo-Controlled Study, Administered by the National Academy of Sciences to Evaluate the Safety and Efficacy of the Narcotic An-tagonist, Naltrexone. Washington, D.C.: Submitted to the National Institute on Drug Abuse (March 30 ).Google Scholar
  2. Bradford, A. and Kaim, S. 1977. Final Report: National Institute on Drug Abuse Studies Evaluating the Safety of the Narcotic Antagonist, Naltrexone. Washington, D.C.: Submitted to the National Institute on Drug Abuse (May 26 ).Google Scholar
  3. Committee on the Clinical Evaluation of Narcotic Antagonists (Division of Medical Sciences Assemby of Life Science National Research Council) 1977. Pilot Studies in the Clinical Evaluation of Narcotic Antagonists.Google Scholar
  4. National Institute on Drug Abuse Research (Monograph Series 9) 1976. Julius, D. and Renault, P. (ads.). Narcotic Antagonists: Naltrexone: Progress Report. Washington, D.C.: U.S. Department of Health, Education and Welfare, pp. 163–171.Google Scholar
  5. National Research Council Committee on Clinical Evaluation of Nar-cotic Antagonists 1978. “Clinical Evaluation of Naltrexone Treatment of Opiate-Dependet Individuals.” Archives of General Psychiatry, 35.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • H. Alex Bradford
    • 1
  • Samuel C. Kaim
    • 1
  • Walter Ling
    • 2
  1. 1.Biometric Research InstituteUSA
  2. 2.Veterans HospitalSepulvedaUSA

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