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Atmospheric Genotoxicants—What Numbers Do We Collect?

  • Eugene Sawicki
Part of the Environmental Science Research book series (ESRH, volume 15)

Abstract

To advance the estimation of human environmental risk, especially cancer prevention, from the body-count phase to realistic extrapolation, we need to carry out more sophisticated carcinogenic studies with animals and submammalian species mimicking the human condition. We have seemingly unsurmountable difficulties with our perspective in the study of human carcinogenesis because the paucity of our environmental data and the simplicity of our carcinogen models of purebred animals and “pure” chemicals so misleads us as to obscure reality. Before we can begin to understand human chemical carcinogenesis, we need to know the genetic background of the individual, the key genotoxicant(s) to which the individual is heavily exposed, and the families of genotoxicants in the individuals environment. We are exposed to genotoxicants because of our particular life style (e.g., cigarette smoking, drugs, medicines, and cosmetics), and because the chemicals are present in the life-supporting environment (e.g., food, water, and air) we share with other people.

Keywords

Vinyl Chloride Styrene Oxide Polluted Atmosphere Respirable Particle Ethylene Dibromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Eugene Sawicki
    • 1
  1. 1.Environmental Sciences Research LaboratoryU.S. Environmental Protection AgencyResearch Triangle ParkUSA

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