The Role of Drosophila in Chemical Mutagenesis Testing

  • Carroll E. Nix
  • Bobbie Brewen
Part of the Environmental Science Research book series (ESRH, volume 15)


An important question facing our society is the impact of numerous chemical insults on the health of man and his environment. Faced with a staggering array of chemicals and enormous testing costs, we can test only a few chemicals for possible carcinogenic effects. Recent results with the Salmonella/mammalian microsome mutagenesis assay developed by Ames (2), demonstrating a striking correlation between carcinogenicity and mutagenicity of many chemical compounds, offer the possibility that mutagenesis assay systems can provide a quick identification of potential carcinogens. Results from microbial assays can serve as a guideline for further mutagenesis testing as well as identify those compounds requiring more extensive analysis in mammalian systems.


Mutagenic Activity Mixed Function Oxidase Synthetic Fuel Staggering Array Recessive Lethal 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Carroll E. Nix
    • 1
  • Bobbie Brewen
    • 1
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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