Mutagenic, Carcinogenic, and Toxic Effects of Residual Organics in Drinking Water

  • John C. Loper
  • Dennis R. Lang
Part of the Environmental Science Research book series (ESRH, volume 15)


Epidemiologic studies have indicated a possible correlation between pollution of drinking water and incidence of cancer. Much of the data for these analyses was collected during the period 1950–1969. Considering the latency period for clinical cancers, the findings contribute to the general concern about long term exposure to the myriad pollutants in our environment.


Drinking Water Reverse Osmosis Colony Count Cellulose Acetate Membrane Strain TA100 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ames BN, McCann J, Yamasaki E: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat Res 31:347–363, 1975Google Scholar
  2. 2.
    Control of organic chemical contaminants in drinking water, Environmental Protection Agency Interim Primary Drinking Water Regulations, U.S. Federal Register 43: 5756–5780, 1978Google Scholar
  3. 3.
    Drinking Water and Health, Report of the National Research Council Safe Drinking Water Committee, National Academy of Science, p 492, 1977Google Scholar
  4. 4.
    Huberman E, Mager R, Sachs L: Mutagenesis and transformation of normal cells by chemical carcinogenesis. Nature 264:360–361, 1976ADSCrossRefGoogle Scholar
  5. 5.
    Kakunaga T: A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB/3T3. Int J Cancer 12:463–473, 1973CrossRefGoogle Scholar
  6. 6.
    Kopf1er FC, Coleman WE, Melton RG, Tardiff RG, Lynch SC, Smith JK: Extraction and identification of organic micropollutants: Reverse osmosis method. Ann NY Acad Sci 298:20–30, 1977ADSCrossRefGoogle Scholar
  7. 7.
    Kraybill HF, Helmes CT, Sigman CC: Biomedical aspects of biorefractories in water. In: Proceedings Second International Symposium on Aquatic Pollutants, Oxford, England: Pergamon Press, Ltd., in pressGoogle Scholar
  8. 8.
    Loper JC, Lang DR, Smith CC: Mutagenicity of complex mixtures from drinking water. In: Proceedings of the Conference on Water Chlorination Environmental Impact and Health Effects, Chapter 33. Ann Arbor Science Publishers, Inc., pp 433–450, 1978Google Scholar
  9. 9.
    Loper JC, Lang DR, Schoeny RS, Richmond BB, Gallagher PM, Smith CC: Residue organic mixtures from drinking water show in vitro mutagenic and transforming activity. Submitted for publicationGoogle Scholar
  10. 10.
    MacPherson I, Montagnier L: Agar suspension culture for the selective assay of cells transformed by polyoma virus. Virology 23:291–294, 1964CrossRefGoogle Scholar
  11. 11.
    Mondai S, Brankow DW, Heidelberger C: Two-stage chemical oncogenesis in cultures of C3H/10T cells. Cancer Res 36:2254–2260, 1976Google Scholar
  12. 12.
    Tardiff RG, Carlson GP, Simmon V: Halogenated organics in tap water: a toxicological evaluation. In: Proceedings Conference on the Environmental Impact of Water Chlorination, pp 213–227, 1975Google Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • John C. Loper
    • 1
  • Dennis R. Lang
    • 1
  1. 1.Department of Microbiology, College of MedicineUniversity of CincinnatiCincinnatiUSA

Personalised recommendations