Short-Term Bioassay of Complex Organic Mixtures: Part I, Chemistry

  • M. R. Guerin
  • B. R. Clark
  • C.-h. Ho
  • J. L. Epler
  • T. K. Rao
Part of the Environmental Science Research book series (ESRH, volume 15)


A multidisciplinary program to elucidate the health and ecological effects of advanced fossil fuels use is currently underway at the Oak Ridge National Laboratory. The development of short-term bioassays applicable to the characterization of complex mixtures is an important aspect of the program. Studies reported here have been designed to identify constituents responsible for the mutagenicity of energy related materials. Observations made in the course of these studies may prove useful for designing biotesting methods suitable for the quantitative routine application to complex mixtures.


Cigarette Smoke Condensate Acetone Fraction Aliphatic Fraction Inhalation Toxicology Complex Organic Mixture 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • M. R. Guerin
    • 1
  • B. R. Clark
    • 1
  • C.-h. Ho
    • 1
  • J. L. Epler
    • 1
  • T. K. Rao
    • 1
  1. 1.Analytical Chemistry and Biology DivisionsOak Ridge National LaboratoryOak RidgeUSA

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