The use of Microbial Assay Systems in the Detection of Environmental Mutagens in Complex Mixtures

  • Herbert S. Rosenkranz
  • Elena C. McCoy
  • Monica Anders
  • William T. Speck
  • David Bickers
Part of the Environmental Science Research book series (ESRH, volume 15)


Microbial mutagenicity procedures are widely used as prescreens for the detection of environmental agents (10,11) endowed with genetic activity. Because of the remarkably good correlation between mutagenicity in bacteria and the potential for causing cancer in animals (13, 29, 30, 58, 59, 63, 76, 78, 91), these short-term assay procedures are also being used to identify potential environmental carcinogens. Our laboratory has participated in several studies dealing with the development, validation, and evaluation of a number of these short-term assay procedures which have included the following: the Salmonella (7), E. coli WP2 uvrA (17,42) and the multipurpose E. coli (66) mutagenicity assays, the host-mediated assay using Salmonella (51) the DNA repair-deficient E. coli (pol A+/pol A1 ) system (83,87), the Saccharomyces cerevisiae mitotic recombination assay (104), and the prophage λ inductest (67).


Flame Retardant Mutagenic Activity Test Strain Test Agent Microsomal Preparation 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Herbert S. Rosenkranz
    • 1
  • Elena C. McCoy
    • 1
  • Monica Anders
    • 1
  • William T. Speck
    • 1
  • David Bickers
    • 1
  1. 1.Department of MicrobiologyNew York Medical CollegeValhallaUSA

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