Development of the Lateral Geniculate Nucleus in Cats Raised with Monocular Eyelid Suture
Since the pioneering work of Wiesel and Hubel (1963a,b; 1965), neurobiologists have appreciated the kitten’s central visual pathways as an elegant model system for studies of the role of the postnatal environment in neural development. A particularly useful approach has been a comparison of the geniculocortical pathways in normally reared cats with those in cats raised with monocular eyelid closure. This paper concentrates on the developmental abnormalities seen in the lateral geniculate nucleus of such monocularly deprived cats. Although most studies of visually deprived cats have focused upon striate cortex, we have emphasized the lateral geniculate nucleus, because an understanding of cortical abnormalities requires a fairly complete description of the status of its geniculate inputs.
KeywordsRetinal Ganglion Cell Lateral Geniculate Nucleus Binocular Competition Spatial Acuity Monocular Deprivation
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