Connectivity of Retinal Projections in Uniocular Mice

  • Pierre Godement
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 27)


The ipsilateral retinal projections to the dorsal lateral geniculate nucleus (dlGn) and to the superior colliculus have been traced in mice either enucleated unilaterally at birth, or bearing a congenital monophthalmy that occurs in the early embryonic life. In both cases, the uncrossed pathway spreads to deafferented regions in the dlGn and superior colliculus. In the dlGn, however, it does not reach the lateral and dorsal borders of the nucleus, and in the superior colliculus only the rostral half contains uncrossed projections. The projections to the superior colliculus are mostly found in the stratum opticum and in the upper stratum griseum superficiale, where they are frequently fragmented in patches of high density of projection.


Retinal Ganglion Cell Superior Colliculus Retinal Projection Dorsal Lateral Geniculate Nucleus Dorsal Border 
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  1. Chase, H. B. (1942). Studies on an anophthalmic strain of mice. III. Results of crosses with other strains. Genetics 27:339–348.PubMedGoogle Scholar
  2. Chase, H. B., and E. B. Chase (1941). Studies on anophthalmic strain of mice. iI. Embryology of the eye region. J. Morphol. 68:279–301.CrossRefGoogle Scholar
  3. Chow, K. L., L. M. Matthews, and P. D. Spear (1973). Spreading of uncrossed retinal projections in superior colliculus of neonatally enucleated rabbits. J. Comp. Neur. 151:307–322.PubMedCrossRefGoogle Scholar
  4. Cunningham, T. J., and J. A. Freeman (1977). Bilateral ganglion cell branches in the normal rat: a demonstration with electrophysiological and cobalt tracing methods. J. Comp. Neur. 172:165–175.PubMedCrossRefGoogle Scholar
  5. Douglas, P., and W. L. Russell (1947). A histological study of eye abnormalities in the C57 black strain of mice. Anat. Record. 91:414.Google Scholar
  6. Fink, R. P., and L. Heimer (1967). Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system. Brain Res. 4:369–374.PubMedCrossRefGoogle Scholar
  7. Frost, D. O., and G. E. Schneider (1976). Normal and abnormal uncrossed retinal projections in Syrian hamsters as demonstrated by Fink-Heimer and autoradiographic techniques. Communication presented at the 6th Annual Meeting of the Society of Neuroscience, Toronto, November 1976.Google Scholar
  8. Godement, P., P. Saillour, and M. Imbert. The ipsilateral optic pathway to the dorsal lateral geniculate nucleus and superior colliculus in mice with pre-or postnatal loss of one eye. J. Comp. Neur., in press.Google Scholar
  9. Guillery, R. W. (1972). Experiments to determine whether retinogeniculate axons can form translaminar collateral sprouts in the dorsal lateral geniculate nucleus of the cat. J. Comp. Neur. 146:407–420.PubMedCrossRefGoogle Scholar
  10. Harch, C., H. B. Chase, and N. I. Gonsalves (1978). Studies on an anophthalmic strain of mice. VI. Lens and cup interaction. Dev. Biol. 63:352–357.PubMedCrossRefGoogle Scholar
  11. Hayhow, W. R., A. Sefton, and C. Webb (1962). Primary optic centers of the rat in relation to the terminal distribution of the crossed and uncrossed optic nerve fibers. J. Comp. Neur. 118:295–321.PubMedCrossRefGoogle Scholar
  12. Lund, R. D. (1975). Variations in the laterality of the central projections of retinal ganglion cells. Exp. Eye Res. 21:193–203.PubMedCrossRefGoogle Scholar
  13. Lund, R. D., T. J. Cunningham, and J. S. Lund (1973). Modified optic projections after unilateral eye removal in young rats. Brain Behav. Evol. 8:51–72.PubMedCrossRefGoogle Scholar
  14. Lund, R. D., and B. F. Miller (1975). Secondary effects of fetal eye damage in rats on intact central optic projections. Brain Res. 92:279–289.PubMedCrossRefGoogle Scholar
  15. Lund, R. D., and J. S. Lund (1976). Plasticity in the developing visual system: the effects of retinal lesions made in young rats. J. Comp. Neur. 169:133–154.PubMedCrossRefGoogle Scholar
  16. Robson, J. A., C. A. Mason, and R. W. Guillery (1978). Terminal arbors of axons that have formed abnormal connections. Science 201:635–637.PubMedCrossRefGoogle Scholar
  17. Silver, J., and A. F. W. Hugues (1974). The relationship between morphogenetic cell death and the development of congenital anophthalmia. J. Comp. Neur. 157:281–302.PubMedCrossRefGoogle Scholar
  18. So, K. F., G. E. Schneider, and D. O. Frost (1978). Postnatal development of retinal projections to the lateral geniculate body in Syrian hamsters. Brain Res. 142:343–352.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Pierre Godement
    • 1
  1. 1.Laboratoire de NeurophysiologieCollège de FranceParisFrance

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