Reversal of the Effects of Visual Deprivation in Monkeys

  • L. J. Garey
  • F. Vital-Durand
  • Colin Blakemore
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 27)


Wiesel and Hubel (1963a,b) found that if the lids of one eye of a kitten were sutured closed soon after birth the neurons of the visual cortex, recorded by extracellular microelectrodes some weeks later, responded almost exclusively to the open eye, the deprived eye losing its ability to drive cortical units. This contrasted with normal cats in which some three-fourths of visual cortical cells were influenced binocularly (Hubel and Wiesel, 1963). Another effect of monocular lid suture was that the neurons in the lateral geniculate nucleus (LGN), innervated by the deprived eye failed to grow fully and were smaller than normally innervated cells. Hubel and Wiesel (1970) defined a “critical” or “sensitive” period from about three weeks to three months postnatally during which these effects could be elicited.

The primate visual system has also been studied with similar experimental procedures, and it has been found that monocular deprivation in the monkey also reduces cortical binocularity (Baker et al., 1974; Crawford et al., 1975; Hubel et al., 1977; Blakemore et al., 1978) and prevents normal neuronal growth in the LGN (Headon and Powell, 1973; von Noorden, 1973; Hubel et al., 1977; Vital-Durand et al., 1978).

In order to investigate the extent to which the changes due to monocular deprivation can be reversed, the technique of “reverse-suture” has been used. The animal is monocularly deprived until cortical and thalamic effects would be expected, and then the closed eye is reopened and the other closed. When done before about 6 weeks of age, in the cat, reverse-suture leads to “recapture” of cortical neurons by the initially deprived eye and to a total reversal of ocular dominance within about two weeks (Blakemore and Van Sluyters, 1974; Movshon, 1976). LGN cells, which are, in the cat, 30 to 40% smaller in cross-sectional area in histological sections in deprived laminae than in non-deprived, recover their size, and are as big as normal cells within three days. Within two weeks they are 30% larger than the newly deprived cells (Dürsteier et al., 1976).

We report here similar experiments performed in the monkey.


Lateral Geniculate Nucleus Ocular Dominance Visual Deprivation Monocular Deprivation Ocular Dominance Column 


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  1. Baker, F. H., P. Grigg, and G. K. Von Noorden (1974). Effects of visual deprivation and strabismus on the response of neurons in the visual cortex of the monkey, including studies on the striate and prestriate cortex in the normal animal. Brain Res. 66:185–208.CrossRefGoogle Scholar
  2. Blakemore, C., L. J. Garey, and F. Vital-Durand (1978). The physiological effects of monocular deprivation and their reversal in the monkey’s visual cortex. J. Physiol. (Lond.) 283:223–262.Google Scholar
  3. Blakemore, C., and R. C. Van Sluyters (1974). Reversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period. J. Physiol. (Lond.) 237:195–216.Google Scholar
  4. Crawford, M. L. J., R. Blake, S. J. Cool, and G. K. Von Noorden (1975). Physiological consequences of unilateral and bilateral eye closure in macaque monkeys: some further observations. Brain Res. 84:150–154.PubMedCrossRefGoogle Scholar
  5. Dürsteier, M. R., L. J. Garey, and J. A. Movshon (1976). Reversal of the morphological effects of monocular deprivation in the kitten’s lateral geniculate nucleus. J. Physiol. (Lond.) 261:189–210.Google Scholar
  6. Garey, L. J., R. A. Fisken, and T. P. S. Powell (1973). Effects of experimental deafferentation on cells in the lateral geniculate nucleus of the cat. Brain Res. 52:363–369.PubMedCrossRefGoogle Scholar
  7. Guillery, R. W. (1972). Binocular competition in the control of geniculate cell growth. J. comp. Neurol. 144:117–130.PubMedCrossRefGoogle Scholar
  8. Guillery, R. W., and D. J. Stelzner (1970). The differential effects of unilateral lid closure upon the monocular and binocular segments of the dorsal lateral geniculate nucleus in the cat. J. comp. Neurol. 139:413–422.PubMedCrossRefGoogle Scholar
  9. Headon, M. P., and T. P. S. Powell (1973). Cellular changes in the lateral geniculate nucleus of infant monkeys after suture of the eyelids. J. Anat. (Lond.) 116:135–145.Google Scholar
  10. Hubel, D. H., and T. N. Wiesel (1963). Receptive fields of cells in striate cortex of very young, visually inexperienced kittens. J. Neurophysiol. 26:994–1002.PubMedGoogle Scholar
  11. Hubel, D. H., and T. N. Wiesel (1970). The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J. Physiol. (Lond.) 206:419–436.Google Scholar
  12. Hubel, D. H., T. N. Wiesel, and S. LeVay (1977). Plasticity of ocular dominance columns in monkey striate cortex. Phil. Trans. R. Soc. B 278:377–409.PubMedCrossRefGoogle Scholar
  13. Movshon, J. A. (1976). Reversal of the physiological effects of monocular deprivation in the kitten’s visual cortex. J. Physiol. (Lond.) 261:125–174.Google Scholar
  14. Vital-Durand, F., L. J. Garey, and C. Blakemore (1978). Monocular and binocular deprivation in the monkey: morphological effects and reversibility. Brain Res. 158:45–64.PubMedCrossRefGoogle Scholar
  15. Von Noorden, G. K. (1973). Histological studies of the visual system in monkeys with experimental amblyopia. Invest. Ophthal. 12:727–738.Google Scholar
  16. Wiesel, T. N., and D. H. Hubel (1963a). Effects of visual deprivation on morphology and physiology of cells in the cat’s lateral geniculate body. J. Neurophysiol. 26:978–993.PubMedGoogle Scholar
  17. Wiesel, T. N., and D. H. Hubel (1963b). Single-cell responses in striate cortex of kittens deprived of vision in one eye. J. Neurophysiol. 26:1003–1017.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • L. J. Garey
    • 1
  • F. Vital-Durand
    • 2
  • Colin Blakemore
    • 3
  1. 1.Institut d’AnatomieUniversity of LausanneLausanneSwitzerland
  2. 2.Laboratoire de Neuropsychologie ExpérimentaleINSERMBronFrance
  3. 3.The Physiological LaboratoryCambridgeEngland

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