Advertisement

Effects of UV Radiation on the Immune System: Consequences for UV Carcinogenesis

  • M. L. Kripke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

Since the early 1900’s, UV light has been suspected of being the causative agent for certain types of human skin cancer (1). Clinical and epidemiological data, as well as animal experiments, have provided strong evidence in support of this hypothesis (2). However, recent evidence from animal studies suggests that UV light can, in addition, affect immunologic functions, and that these immunologic perturbations may be important in the pathogenesis of UV light-induced skin cancer.

Keywords

Spleen Cell Hind Footpad Transient Depression Human Skin Cancer Normal Spleen Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dubreuilh, W. Annal. Dermat. Syph. viii (1907) 387.Google Scholar
  2. 2.
    Emmet, E. A. Crit. Rev. Toxicol. 2 (1973) 211.CrossRefGoogle Scholar
  3. 3.
    Feldmann, M. Nature New Biol. 242 (1973) 82.Google Scholar
  4. 4.
    Fisher, M. S. and Kripke, M. L. Proc. Natl. Acad. Sci., USA, 74 (1977) 1688.PubMedCrossRefGoogle Scholar
  5. 5.
    Fisher, M. S. and Kripke, M. L. Immunol., in press.Google Scholar
  6. 6.
    Jessup, J. M., Cohen, M. H., Tomaschewski, M. M. and Felix, E. L. J. Natl. Cancer Inst. 57 (1976) 1077.PubMedGoogle Scholar
  7. 7.
    Jessup, J. M., Hanna, N., Palaszynski, E. and Kripke, M. L. Cell. Immunol. 38 (1978) 105.PubMedCrossRefGoogle Scholar
  8. 8.
    Kripke, M.L. J. Natl. Cancer Inst. 53 (1974) 1333.PubMedGoogle Scholar
  9. 9.
    Kripke, M.L. Photochem. Photobiol. 24 (1976) 599.PubMedCrossRefGoogle Scholar
  10. 10.
    Kripke, M.L. Photochem. Photobiol. 24 (1976) 599.PubMedCrossRefGoogle Scholar
  11. 11.
    Kripke, M.L. Cancer Res. 37 (1977) 1395.PubMedGoogle Scholar
  12. 12.
    Kripke, M.L. and Fisher, M. S. J. Reticuloendothel. Soc. 22 (1976) 599.Google Scholar
  13. 13.
    Kripke, M.L. Lofgreen, J. S., Beard, J., Jessup, J. M. and Fisher, M.S. J. Natl. Cancer Inst. 59 (1977) 1227.Google Scholar
  14. 14.
    Norbury, K.C. Kripke, M. L. and Budmen, M. B. J. Natl. Cancer Inst. 59 (1977) 1231.Google Scholar
  15. 15.
    Stingl, G., Katz, S. I., Shevach, E. M., Schreiner, E. and Green, I. J. J.Immunol. 120 (1978) 570.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • M. L. Kripke
    • 1
  1. 1.Cancer Biology ProgramNCI Frederick Cancer Research CenterFrederickUSA

Personalised recommendations