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Tobacco Smoke and the Pulmonary Alveolar Macrophage

  • D. B. Drath
  • P. Davies
  • M. L. Karnovsky
  • G. L. Huber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

The pulmonary alveolar macrophage (PAM) has been shown by numerous investigators to be responsible for maintaining sterility of the lower respiratory tract (4, 8). This key host defense cell must interact with and destroy invading microorganisms, as well as inactivate and remove various non-viable particulates to which the lung is exposed. Perhaps the most common particulate in this class is tobacco smoke, a complex chemical aerosol comprised of over 3,000 separate gaseous, liquid and solid components. The lung is the primary target organ affected by tobacco smoke and the first line of resistance to the inhaled smoking products is the alveolar macrophage. Failure on the part of this phagocyte to deal effectively with this environmental inhalant could conceivably lead to an increased susceptibility to microbial infection, as well as an altered pulmonary integrity. We have investigated, therefore, the effects of tobacco smoke on the structure, function, and metabolism of alveolar macrophages harvested by bronchopulmonary lavage from rats previously exposed to carefully quantified dosages of tobacco smoke for periods of 30–180 consecutive days.

Keywords

Tobacco Smoke Alveolar Macrophage Volume Density Smoke Exposure Oxygen Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Davies, P., Sornberger, G. C. and Huber, G. L. Amer. Rev. Resp. Dis. 116 (1977) 1113.Google Scholar
  2. 2.
    Davies, P., Sornberger, G. C. and Huber, G. L. Lab. Invest. 37 (1977) 297.PubMedGoogle Scholar
  3. 3.
    Drath, D. B. and Karnovsky, M. L. J. Exp. Med. 145 (1975) 257.Google Scholar
  4. 4.
    Green, G. M. Ann. Rev. Med. 19 (1968) 315.PubMedCrossRefGoogle Scholar
  5. 5.
    Green, G. M., Powell, G. M. and Moriss, T. G. J. Clin. Invest. 50 (1971) 40a.Google Scholar
  6. 6.
    Gross, P. and DeTreville, R. T. P. Arch. Environ. Hlth. 17 (1968) 720.Google Scholar
  7. 7.
    Harris, J. O., Swenson, E. W. and Johnson, J. E. J. Clin. Invest. 49 (1970) 2086.Google Scholar
  8. 8.
    Huber, G. L., Johanson, W. G. and LaForce, F. M. In: Lung biology in health and disease (Ed. C. Lenfant) Vol. 5, Marcel Dekker, Inc. New York (1977) 979.Google Scholar
  9. 9.
    Huber, G. L., Pochay, V. E., Mahajan, V. K., McCarthy, C. R. Hinds, W. C., Davies, P., Drath, D. B. and Sornberger, G. C. Bull. Eur. Physiopathol. Respir. 13 (1977) 145.PubMedGoogle Scholar
  10. 10.
    Karnovsky, M. L., Lazdins, J. and Simmons, S. In: Mononuclear phagocytes in immunity, infection and pathology (Ed. R. Van Furth ), Blackwell Scientific Publications, Oxford, England (1975) 423.Google Scholar
  11. 11.
    LaForce, F. M., Kelly, W. J. and Huber, G. L. Am. Rev. Resp. Dis. 108 (1973) 784.PubMedGoogle Scholar
  12. 12.
    MacKaness, G. B. J. Expt. Med. 120 (1964) 105.CrossRefGoogle Scholar
  13. 13.
    Matulionis, D. H. and Traurig, H. H. Lab. Invest. 37 (1977) 314.PubMedGoogle Scholar
  14. 14.
    Michell, R. H., Pancake, S. J., Moseworthy, J. and Karnovsky, M. L. J. Cell. Biol. (1969) 216.Google Scholar
  15. 15.
    Pratt, S. A., Smith, M. H., Ladman, A. J. and Finley, T. N. Lab. Invest. 24 (1971) 331.PubMedGoogle Scholar
  16. 16.
    Root, R. K., Metcalf, J., Oshino, M. and Chance, B. J. Clin. Invest. 55 (1974) 945.Google Scholar
  17. 17.
    Salin, M. L. and McCord, J. M. Clin. Invest. 56 (1975) 1319.Google Scholar
  18. 18.
    Sorokin, S. O. In: Lung biology in health and disease (Ed. C. Lenfant) Vol. 5, Marcel Dekker, Inc., New York (1977) 711.Google Scholar
  19. 19.
    Underwood, E. E. In: Quantitative stereology. Addison-Wesley, Reading, Massachusetts (1970) 119.Google Scholar
  20. 20.
    Vassar, P. S., Culling, C., Saunders, A. M. Arch. Pathol. 70 (1960) 649.PubMedGoogle Scholar
  21. 21.
    Warr, G. A. and Martin, R. R. J. Reticuloendo. Soc. 23 (1978) 53.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • D. B. Drath
    • 1
  • P. Davies
    • 1
  • M. L. Karnovsky
    • 1
  • G. L. Huber
    • 1
  1. 1.Harvard Medical School and Beth Israel HospitalBostonUSA

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