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Alveolar Macrophage — Splenic Lymphocyte Interactions Following Chronic Asbestos Inhalation in the Rat

  • E. Kagan
  • K. Miller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

While the alveolar macrophage undoubtedly plays a crucial role in the early stages of asbestosis (3,24) little is known about the possible contribution of the immune system to the pathogenesis of this disorder. There is evidence, from a number of clinical studies, which suggests that some disturbance of immunoregulation may be operative in patients with asbestosis. Impaired expression of several parameters of cell-mediated immunity has been demonstrated both in vivo (8,10) and in vitro (7,8,10), in such patients. In contrast, these patients manifest hyperactivity of the humoral immune response, as evidenced by their increased production of serum immunoglobulins (9,11), secretory IgA (9) and a variety of autoantibodies (9,11,30).

Keywords

Alveolar Macrophage Splenic Lymphocyte Lymphocyte Blastogenesis Control Macrophage Crocidolite Asbestos 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • E. Kagan
    • 1
  • K. Miller
    • 2
  1. 1.Georgetown University Medical CenterUSA
  2. 2.National Research Institute for Occupational DiseasesJohannesburgSouth Africa

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