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Function of Macrophage Prostaglandins in the Process of Phagocytosis

  • E. Razin
  • U. Zor
  • A. Globerson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

Prostaglandins (PGs) act as mediators in inflammation and cell-mediated immune responses (1,5,9). Since macrophages participate in the inflammatory reaction, studies were focused on the effects of PGs on macrophage functions. It has been demonstrated that addition of PGs at low doses enhances phagocytosis (8), whereas at pharmacological concentrations phagocytosis is inhibited (2,7,8,10). Furthermore, macrophages were shown to synthesize PGs (3,4), and this process is enhanced by phagocytized particles (6). We therefore attempted to find out whether synthesis of PGs by the macrophage may play a role in phagocytosis.

Keywords

Oleic Acid Adherent Cell Weizmann Institute Upjohn Company Phosphate Buffer Saline Control 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • E. Razin
    • 1
  • U. Zor
    • 2
  • A. Globerson
    • 1
  1. 1.Departments of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael
  2. 2.Departments of Hormone ResearchThe Weizmann Institute of ScienceRehovotIsrael

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