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Role of Res and Leukocytic Endogenous Mediator in Iron, Zinc and Copper Metabolism

  • R. F. Kampschmidt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

The reticuloendothelial system (RES) influences metal metabolism in the body in many different ways. The most thoroughly studied metal is iron, and its relationship with the RES has been frequently reviewed (1, 10, 22, 24). Substantial quantities of zinc occur in phagocytic cells and there is evidence that zinc has a role in membrane stability and phagocytosis (4). During infectious diseases or other inflammatory stresses the absorption, storage and plasma levels of zinc are altered (27). The most clearly defined interaction between copper and the RES is the role of ceruloplasmin in regulating the movement of iron from the RES to transferrin (39). Iron is conserved by the body and its major use is in the formation of the hemoglobin found in erythrocytes. Aged erythrocytes are removed from the blood by the RES and the major portion of the iron is recycled to the bone marrow through the iron transport protein (transferrin). Although most of the iron is used for new hemoglobin synthesis, a small amount is stored in the RES for varying periods of time.

Keywords

Iron Metabolism Plasma Zinc Plasma Iron Plasma Copper Hemoglobin Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • R. F. Kampschmidt
    • 1
  1. 1.Biomedical DivisionThe Samuel Roberts Noble FoundationArdmoreUSA

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